Pharma Syllabus

SYLLABUS FOR B. PHARM (Bachelor of Pharmacy).

According to the All India Council for Technical Education (AICTE)

B.Pharm Subjects:

Semester I

1 Pharmaceutical Analysis-I
2. Remedial Mathematics Biology
3. Pharmacognosy-I
4. Pharmaceutical Chemistry-I (Inorganic Pharmaceutical Chemistry)
5. Basic Electronics & Computer Applications

Semester II

1. Pharmaceutics -I (Physical Pharmacy)
2. Advanced Mathematics
3. Pharmaceutical Chemistry -II (Physical Chemistry)
4. Pharmaceutical Chemistry-III (Organic Chemistry-I)
5. Anatomy, Physiology & Health Education (APHE) -I 

Semester III

1. Pharmaceutics -II (Unit Operations _ I, including Engg. Drawing)
2. Pharmaceutical Chemistry-IV (Organic Chemistry - II)
3. Pharmacognosy -II
4. Pharmaceutical Analysis - II
5. A P HE-II

Semester IV

1. Pharmaceutics - III (Unit Operations - II)
2. Pharmaceutical Microbiology 
3. Pharmacognosy - III
4. Pathophysiology of Common Diseases
5. Pharmaceutics (Dispensing & Community Pharmacy)

Semester V

1. Pharmaceutical Chemistry - V (Biochemistry)
2. Pharmaceutics - V (Pharmaceutical Technology I)
3. Pharmacology - I
4. Pharmacognosy -N
5. Pharmaceutics -VI (Hospital pharmacy)

Semester VI

1. Pharmaceutical Chemistry - VI (Medicinal Chemistry -I)
2. Pharmaceutical Jurisprudence & Ethics
3. Pharmaceutics -VII (Biopharmaceutics & Pharmacokinetics)
4. Pharmacology -II
5. Pharmacognosy - V (Chemistry of Natural Products)

Semester VII

1. Pharmaceutical Biotechnology
2. Pharmaceutics - VIII (Pharmaceutical Technology - II)
3 Pharmaceutical Industrial Management
4. Pharmacology -III 
5. Pharmaceutical Chemistry-VII (Medicinal Chemistry - II)
6. Elective (Theory)

Semester VIII

1. Pharmaceutics - IX
2. Pharmaceutical Analysis - III
3. Pharmaceutical Chemistry - VIII (Medicinal Chemistry - III)
4. Pharmacognosy - VI
5. Pharmacology - IV (Clinical Pharmacy & Drug Interactions)
6. Project

Pharmaceutical Analysis- I (B.Pharm Sem-I)

Theory-

1. Significance of quantitative analysis in quality control, Different techniques of
analysis, Preliminaries, and definitions, Significant figures, Rules for retaining
significant digits, Types of errors, Mean deviation, Standard deviation, Statistical
treatment of small data sets, Selection of sample, Precision, and accuracy.
Fundamentals of volumetric analysis, methods of expressing concentration,
primary and secondary standards.

2. Acid-Base Titrations: Acid-base concepts, Role of solvent, Relative strengths of

acids and bases, Ionization, Law of mass action, Communion effect, Ionic product
of water, pH, Hydrolysis of salts, Henderson-Hessel bach equation, Buffer
solutions, Neutralization curves, Acid-base indicators,·' Theory of indicators,
Choice of indicators, mixed indicators, Polyprotic system, Polyamine, and amino
acid systems, Amino acid titration, applications in the assay of Hl04, NaOH, CaC03
etc.

3. Oxidation Reduction Titrations: Concepts of oxidation and reduction, Redox reactions, Strengths, and equivalent weights of oxidizing and reducing agents, Theory of redox titrations, Redox indicators, Cell representations, Measurement of electrode potential, Oxidation-reduction curves, Iodimetry and Iodometry, Titrations involving ceric sulfate, potassium iodate, potassium bromate, potassium permanganate; titanous chloride and Sodium 2, 6-dichlorophenol indophenol.

4. Precipitation Titrations: Precipitation reactions, Solubility products, Effect of acids, temperature, and solvent upon the solubility of a precipitate. Argentometric titrations and titrations involving ammonium or potassium thiocyanate, mercuric nitrate, and barium sulfate, Indicators, Gaylussac method; Mohrs method, Volhard's method, and Fagan's method.

5. Gravimetric Analysis: Precipitation techniques, Solubility products; The colloidal state, Supersaturation co-precipitation, Postprecipitation, Digestional washing of the precipitate, Filtration, Filter papers and crucibles, Ignition, Thermogravimetric curves, Specific examples like barium sulfate, aluminum as aluminum oxide, calcium as calcium oxalate and magnesium as magnesium pyrophosphate, Organic precipitants.

Practicals-

The students should be introduced to the main analytical tools through demonstrations. They should have a clear understanding of a typical analytical balance, the requirements of a good balance, weights, care and use of balance, methods of weighing, and errors in weighing. The students should also be acquainted with the general apparatus required in various analytical procedures.

1. Standardization of analytical weights and calibration of volumetric apparatus.

2. Acid-Base Titration: Preparation and standardization of acids and bases; some exercises related to the determination of acids and bases separately or in mixture form, some official assay procedures e.g. boric acid should also be covered.

3. Oxidation Reduction Titrations: Preparation and standardization of some redox titrants e.g. potassium permanganate, potassium dichromate, iodine, sodium thiosulphate, etc. Some exercises related to the determination of oxidizing and reducing agents in the sample shall be covered. Exercises involving potassium iodate, potassium bromate, iodine solution, titanous chloride, sodium 2, 6 dichlorophenol indophenol, and ceric ammonium sulfate.

4. Precipitation titrations: Preparation and standardization of titrants like silver nitrate and, ammonium thiocyanate, Titrations according to Mohr's, Volhard's, and Fagan's methods.

5. Gravimetric Analysis: Preparation of gooch crucible for filtration and use of sintered glass crucible, Determination of water of hydration, Some exercises related to gravimetric analysis should be covered.

Remedial Mathematics (B.Pharm Sem-I)

Theory-

1. Algebra: Equations reducible to quadratics, simultaneous equations (linear and quadratic), Determinants, properties of the solution of simultaneous equations by Cramer's rule, matrices, the definition of special kinds of matrices, arithmetic operations on matrices, the inverse of a matrix, solution of simultaneous equations by matrices, pharmaceutical applications of determinants and matrices. Evaluation of Enl, En2, and En3, mensuration and its pharmaceutical applications.

2. Measures of Central Value: Objectives and pre-requisites of an ideal, measure, mean, mode, and median.

3. Trigonometry: Measurement of angle, T-ratios, addition, subtraction and transformation formulae, T -ratios of multiple, submultiple, allied, and certain angles. Application of logarithms in pharmaceutical computations.

4. Analytical Plans Geometry: Certain coordinates, distance between two points, area of the triangle, a locus of a point, straight line., slope and intercept from, double intercept form, normal (perpendicular form), slope-point and two-point form, general equation of first degree.

5. Calculus : Differential: Limits and functions, the definition of differential coefficient, differentiation of standard functions, including the function of a function (Chain rule). Differentiation of implicit functions, logarithmic differentiation, parametric differentiation, successive differentiation. Integral: Integration as inverse of differentiation, indefinite integrals of standard forms, integration by parts, substitution and partial fractions, formal evaluation of definite
integrals.

Remedial Biology (B.Pharm Sem-I)

Theory

1. Methods of classification of plants.

2. Plant Cell: Its structure and non-living inclusions; mitosis and meiosis; different types of plant tissues and their functions.

3. Morphology and histology of root, stem, bark, wood, leaf, flower fruit, and seed. Modification of root and stem.

4. General Survey of Animal Kingdom; Structure and life history of parasites as illustrated by amoeba, entamoeba, Trypanosoma, plasmodium, taenia, Ascaris, Schistosoma, oxyuris, and ancylostoma.

5. General Structure and life history of insects like mosquitoes, houseflies, mites, and silkworms.

Practical

l. Morphology of plant parts indicated in theory.

2 Care, use, and type of microscopes.

3. Gross identification of slides of structure and life cycle of lower plants animals mentioned in theory.

4. Morphology of plant parts indicated in theory

5. Preparation, microscopic examination of stem, root, and leaf of monocot and dicot plants

6. Structure of human parasites and insects mentioned in theory with the help of specimens

Pharmacognosy-I (B.Pharm Sem-I)

Theory

1. Definition, history, scope, and development of Pharmacognosy

2. Sources of drugs: Biological, marine, mineral, and plant tissue cultures as sources of drugs

3. Classification of drugs: Alphabetical, morphological, taxonomical, chemical, and pharmacological classification of drugs

4. Plant taxonomy: Study of the following families with special reference to medicinally important plants – Apocynaceae, Solanaceae, Rutaceae, Umbelliferae, Leguminosae, Rubiaceae, Liliaceae, Graminae, Labiatae, Cruciferae, Papaveraceae.

5. Cultivation, Collection, Processing and storage of crude drugs: Factors influencing cultivation of medicinal plants. Types of soils and fertilizers of common use. Pest management and natural pest control agents. Plant hormones and their applications. Polyploidy, mutation, and hybridization with reference to medicinal plants.

6. Quality control of cr4ude drugs: Adulteration of crude drugs and their detection by organoleptic, microscopic, physical, chemical, and biological methods and properties.

7. An introduction to active constituents of drugs: their isolation, classification, and properties.

8. Systematic pharmacognostic study of following

• Carbohydrates and derived products: agar, guar gum acacia, Honey, Isabgol, pectin, Starch, sterculia, and Tragacanth.
• Lipids: Beeswax, Castor oil, Cocoa butter, Cod~liver oil, Hydnocarpus oil, Kokum Butter, Lard, Linseed oil, Rice, Bran oil, Shark liver oil, and Wool fat.

Practicals

1. Morphological characteristics of plant families mentioned in theory.

2. Microscopic measurements of cells and Cell contents: Starch grains, calcium oxalate crystals, and phloem fibers.

3. Determination of leaf constants such as stomatal index, stomatal number, vein islet number, vein-termination number, and palisade ratio.

4. Identification of crude drugs belonging to carbohydrates and lipids.

5. Preparation of herbarium sheets.

Pharmaceutical Chemistry - I (B.Pharm Sem-I)

(Inorganic Pharmaceutical Chemistry)

Theory

An outline of methods of preparation, uses, sources of impurities, tests for purity and
identity, including limit tests for iron, arsenic, lead, heavy metals, chloride, sulphate and
special tests if any, of the following classes of inorganic pharmaceuticals included in
Indian Pharmacopoeia.

1. Acids and Bases: Buffers, Water.

2. Gastrointestinal Agents : Acidifying agents, Antacids, Protectives and Adsorbents, Cathartics.

3. Major Intra-and Extra-cellular Electrolytes: Physiological ions. Electrolytes are used for replacement therapy, acid-base balance and combination therapy.

4. Essential and Trace Elements: Transition elements and their compounds of pharmaceutical importance: Iron and haematinics, mineral supplements.

5. Cationic and anionic components of inorganic drugs useful for systemic effects.

6. Topical Agents: Protectives, Astringents and Anti-infectives.

7. Gases and Vapours : Oxygen, Anesthetics and Respiratory . stimulants.

8. Dental Products: Dentifrice, Anti-caries agents.

9. Complexing and chelating agents used in therapy

10. Miscellaneous Agents: Sclerosing agents, expectorants, emetics, poisons and antidotes, sedatives etc. Pharmaceutical Aids Used in Pharmaceutical Industry. Anti-oxidants, preservatives, filter aids, adsorbents, diluents, excipients, suspending agents, colorants etc.

11. Inorganic Radio Pharmaceuticals: Nuclear radio pharmaceuticals, Reactions, Nomenclature, Methods of obtaining their standards and units of activity, measurement of activity, clinical applications and dosage, hazards, and precautions.

Practicals

The background and systematic qualitative analysis of inorganic mixtures of up to four radicals. Six Mixtures to be analyzed, preferably by semi-micro methods. At identification tests for pharmacopoeial inorganic pharmaceuticals and qualitative tests for cations & anions should be covered.

Basic Electronics and Computer Applications (B.Pharm Sem-I)

Theory

1. Basic Electronics: Semiconductors, p-n function diode, LED, photodiode and its uses. Rectifiers (half wave, full wave/ with filters) Transistors configurations, Transistor amplifiers. Introduction to Integrated circuits, photocells, and photomultiplier tubes.

2. Computers :

Introduction to Computers.

2. 1. History of Computer development and respective generation: Abacus, Napier'sBones, Slide rule, Pascal's Calculator. Need to use computers, applications in pharmacy and in general. Computer Classification: Mainframe, Mini and Micro Computers, comparison of Analog & Digital Computers, Hardware and Software. Calculator and Computer.

2.2. Operating Systems: Introduction to types of operating systems, UNIX, MS-DOS, etc. RAM, ROM, Virtual Memory, etc.

2.3. Type of Languages: Conventional languages; their advantages, limitations; C, Pascal, FORTRAN, Programming of these languages.

 
2.4. Introduction to Computer Networks: Architecture of seven layers of communications.

2.5. Introduction to Data Structure: Like Queues, list, trees, Binary trees algorithms, Flow chart, Structured Systems, Analysis and development, Ingress-SQL, Gateways, etc. Statistics, methodologies.

Basic Language: 

Constants and Variables: Character set, constants, variables, Naming the variables getting data into memory, LET, INPUT, READ. DATA, Print Statement.

Expressions: Arithmetic expression, Hierarchy of operations, Rules of Arithmetic, Evaluation of expressions, Relational expressions, Logical operations, Library functions.

Printer Control: Comma and semicolon control, the TAB function, PRINT, LPRINT.

Functions and Subroutines: User-defined functions, subroutines, subscripted variables.

2.6. Computer Graphics:

2.7. Computer applications in pharmaceutical and clinical studies.

Practicals

Exercises based on the following are to be dealt:

1. Computer operating systems like Unix, MS-DOS, etc.

2. Simple program in BASIC

3. Study of soft-ware packages like WORD-STAR, LOTUS-123 etc.

Pharmaceutics - I (B.Pharm Sem-I)

(Physical Pharmacy)

Theory

1. Matter, Properties of Matter: State of matter, change in the state of matter, latent heat and vapor pressure, sublimation-critical point, Eutectic mixtures, gases, aerosols-inhalers, relative humidity, liquid. complexes, liquid crystals, glassy state, solids-crystalline, amorphous and polymorphism.

2. Micromeretic and Powder Rheology: Particle size and distribution, average particle size, number and weight distribution, particle number, methods for determining particle volume, optical microscopy, Asieving, sedimentation, measurement, particle shape, specific surface, methods for determining surface area; permeability, adsorption, derived properties of powders, porosity, packing arrangement, densities, bulkiness & flow properties.

3. Surface and Interfacial Phenomenon: Liquid interface, surface, and interfacial tensions, surface free energy, measurement of surface and interfacial tensions, spreading coefficient, adsorption at liquid interfaces, surface-active agents, HLB classification, solubilization, detergency, adsorption at solid interfaces, solid-gas and solid-liquid interfaces, complex films, electrical properties 0-meter ace.

4. Viscosity and Rheology: Newtonian systems, Law of flow, kinematic viscosity, the effect of temperature, non-Newtonian systems, pseudoplastic, dilatant, plastic, thixotropy, thixotropy in formulation, determination of viscosity, capillary, falling ball, rotational viscometers.

5. Dispersion Systems: Colloidal Dispersions: Definition, Types, properties of colloids, protective colloids, applications of colloids in pharmacy; Suspensions and Emulsions: Interfacial properties of suspended particles, settling in suspensions, theory of sedimentation, effect of Brownian movement" sedimentation of flocculated articles, sedimentation parameters, wetting of particles, controlled flocculation, flocculation in structured vehicles, rheological considerations; Emulsions-types, theories, physical stability.

6. Complexation: Classification of complexes, methods of preparation and analysis, applications.

7. Kinetics and Drug Stability: General considerations & concepts, half-life determination, Influence of temperature, light, solvent, catalytic species and other factors, Accelerated stability study, expiration dating.

8. Buffers: Buffer equations and buffer capacity in general, buffers in pharmaceutical systems, preparation, stability, buffered isotonic solutions, measurements of tonicity, calculations, and methods of adjusting isotonicity.

Practicals

1. Determination of latent heat, vapor pressure, critical point.

2. Studies on polymorphs, their identification and properties.

3. Determination of particle size, particle size distribution, and surface area using various methods of particle size analysis.

4. Determination of derived properties of powders like density, porosity, compressibility, angle of repose etc.

5. Determination of surface/interfacial tension, HLB value and critical micellar concentration of surfactants.

6. Study of rheological properties of various types of systems using different Viscometers.

7. Studies of different types of colloids and their properties.

8. Preparation of various types of suspensions and determination of their sedimentation parameters.

9. Preparation and stability studies of emulsions.

10. Studies on different types of complexes and determination of their stability constants.

11. Determination of half-life, rate constant and order of reaction.

 
12. To study the influence of various factors on the rate of reaction.

13. Accelerated stability testing, shelf-life determination and expiration dating of pharmaceuticals.

14. Preparation of pharmaceutical buffers and determination of buffer capacity.

15. Experiments involving tonicity adjustments.

Advanced Mathematics (B.Pharm Sem-II)

Theory

1. Differential equations: Revision of integral calculus, definition and formation of differential equations, equations of first order and first degree, variable separable, homogeneous, and linear differential equations and equations reducible to such types, linear differential equations of order greater than one with constant coefficients, complementary function and particular integral, simultaneous linear differential equations, pharmaceutical applications.

2. Laplace transforms: Definition, transforms of elementary functions, properties of linearity and shifting, inverse Laplace transforms, transforms of derivatives, solution of ordinary and simultaneous differential equations.

3. Biometrics: Significant digits bend rounding of numbers, data collection, random and non-random sampling methods, sample size, data organization, diagrammatic representation of data, bar, pie, 2-D and 3-D diagrams, measures of central tendency, measures of dispersion, Standard Deviation and standard error of means, coefficient of variation, confidence (fiducial) limits, probability and
events, Bayes' theorem, probability theorems, probability distributions, elements of binomial and Poisson distribution, Normal Distribution curve & properties, kurtosis and skewness, correlation and regression analysis, method of least squares, statistical inference, Student's and paired t-test, F-test and elements of ANOVA, applications of statistical concepts in Pharmaceutical Sciences.

Pharmaceutical Chemistry - II (B.Pharm Sem-II)

(Physical Chemistry)

Theory

1. Behaviour of Gases: Kinetic theory of gases, deviation from behaviours and explanation.

2. The Liquid State: Physical properties (surface tension, paracord, viscosity, refractive index, optical rotation, dipole moments and chemical constituents).

3. Solutions: Ideal and real solutions, solutions of gases in liquids, colligative properties, partition coefficient, conductance and its measurement, Debye Huckel theory.

 
4. There dynamics: First, second and third laws, Zeroth law, absolute temperature scale, thermochemical equations, phase equilibria, and phase rule.

5. Adsorption: Freundlich and Gibbs adsorption, isotherms, Langmuir theory of adsorption.

6. Photochemistry: Consequences of light absorption, Jablonski diagram, LambertBeer Law, Quantum efficiency.

7. Chemical Kincties: Zero, first and second-order reactions, complex reactions, theories of reaction kinetics, characteristics of homogeneous and heterogeneous catalysis, acid-base and enzyme catalysis.

8. Quantum Mechanics : Postulates of quantum mechanics, operators in quantum mechanics, the Schroedinger wave equation.

Practicals

1. To determine molar mass by Rast method and cryoscopic method.

2. To determine refractive index of given liquids and find out the contribution of carbon, hydrogen and oxygen in molar refraction of a compound.

3. To determine molar mass of volatile liquids by Victor-Meyer method.

4. To determine the specific rotation of sucrose at various concentrations and determine the intrinsic rotation.

5. To determine the heat of solution, heat of hydration and heat of neutralization.

6. To determine the cell constant, verify Ostwald dilution law and perform conductometric titration,.

7. To determine rate constant of simple reaction.

Pharmaceutical Chemistry - III (B.Pharm Sem-II)

(Organic Chemistry)

Theory

The subject of organic chemistry will be treated in its modem perspective keeping for the sake of convenience, the usual classification of 'organic compounds.:

1. Structure and Properties: Atomic structure, Atomic orbitals, Molecular orbital theory, wave equation, Molecular orbitals, Bonding and Antibonding orbitals, Covalent bond, Hybrid orbitals, Intramolecular forces, Bond dissociation energy, Polarity of bonds, Polarity of molecules, structure, and physical properties, Intermolecular forces, Acids and bases.

2. Stereochemistry: Isomerism and nomenclature and associated physicochemical properties, optical activity, stereoisomerism, specification of configuration, Reactions involving stereoisomers, chirality, chiral reagents conformations.

 
3. Structure; Nomenclature; Preparation and Reactions of: Alkanes, Alkenes, Alkynes; Cycloalkanes, Dienes, Benzene, Polynuclear aromatic compounds, Arenes, Alkyl halides, Alcohols, Ethers, Epoxides, Amines, Phenols, Aldeh¥des and ketones, Carboxylic acids, Functional derivatives of' carboxylic acids, Reactive intermediates - carbocations, carbanions, carbenes, nitrene and nitrenium
ions.

Practicals

1. The student should be introduced to the various laboratory techniques through demonstrations involving synthesis of selected organic compounds (e.g. aspirin, p-bromoacetanilide, anthraquinone from anthracene, reduction of nitrobenzene, etc)

2. Identification of organic compounds and their derivatisation.

3. Introduction to the use of stereo models.

Anatomy, Physiology & Health Education (B.Pharm Sem-II)

Theory

1. Scope of anatomy and physiology and basic terminology used these subjects.

2. Structure of cell, its components and their functions.

3. Elementary Tissues of the Human Body: Epithelial, connective, muscular, and nervous tissues, their sub-types, and their characteristics.

4. Osseous System: Structure, composition and functions of skeleton Classification of joints, types of movements of joints, Disorders of joints.

5. Skeletal Muscles: Gross anatomy; physiology of muscle contraction, physiological properties of skeletal muscles and their disorders.

6. Haemopoietic System: Composition and functions of blood and its elements, their disorders, blood groups and their significance, mechanism of coagulation, disorders of platelets, and coagulation.

7. Lymph and Lymphatic System: Composition, formulation, and circulation of lymph; disorders of lymph and lymphatic system. Basic physiology and functions of the spleen.

8. Cardiovascular System: Basic anatomy of the heart, Physiology of heart, blood vessels, and circulation. Basic understanding of Cardiac cycle, heart sounds, and understanding of Cardiac cycle, heart sounds, and electrocardiogram. Blood pressure and its regulation. Brief outline of cardiovascular disorder like hypertension, hypotension, arteriosclerosis, angina, myocardial infarction, congestive heart failure, and cardiac arrhythmias.

 

Practicals

1. Study of human skeleton.

2. Study of different systems with the help of charts and models.

3. Microscopic study of different tissues.

4. Estimation of haemoglobin in blood. Determination of bleeding time, clotting time, R.B.C. Count, Total leucocyte count, D.L.C. and E.S.R.

5. Recording of body temperature, pulse rate, and blood pressure, a basic understanding of Electrocardiogram- PQRST waves and their significance.

Pharmaceutics - II (B.Pharm Sem-III)

(Unit Operations I)

Theory

1. Unit Operations: Introduction, basic laws.

2. Fluid Flow: Types of flow, Reynold's number, Viscosity, Concept of the boundary layer, basic equations of fluid flow, valves, flow meters, manometers, and measurement of flow and pressure.

3. Material Handling Systems:

• Liquid handling - Different types of pumps.
• Gas handling-Various types of fans, blowers and compressors.
• Solid handling-Bins, Bunkers, Conveyers, Air transport.

4. Filtration and Centrifugation: Theory of filtration, filter aids, filter media, industrial filters including filter press, rotary filter, edge filter, etc. Factors affecting filtration, mathematical problems on filtration, optimum cleaning cycle in batch filters. Principles of centrifugation, industrial centrifugal filters, and centrifugal sediments.

5. Crystallization: Characteristics of crystals like-purity, size, shape, geometry, habit, forms size and factors affecting them, Solubility curves and calculation of yields. Material and heat balances around Swenson Walker Crystallizer. Supersaturation theory and its limitations, Nucleation mechanisms, crystal growth. Study of various types of Crystallizer, tanks, agitated batch, Swenson Walker, Single
vacuum, circulating magma and crystal Crystallizer, Caking of crystals and its prevention. Numerical problems on yields.

6. Dehumidification and Humidity Control: Basic concepts and definition, wet bulb and adiabatic saturation temperatures, Psychrometric chart, and measurement of humidity, application of humidity measurement in pharmacy, equipments for dehumidification operations.

7. Refrigeration and Air Conditioning: Principal and applications of refrigeration and air conditioning.

8. Material of Construction: General study of composition, corrosion, resistance, Properties, and applications of the materials of construction with special reference to stainless steel and glass.

9. Industrial Hazards and Safety Precautions: Mechanical, Chemical, Electrical, fire, and dust hazards. Industrial dermatitis, Accident records etc.

Practicals

1. Measurement of flow of fluids and their pressure, determination of Reynold's number, and calculation of Frictional losses.

2. Evaluation of filter media, determination of rate of filtration and study of factors affecting filtration.

3. Experiments to demonstrate applications of centrifugation.

4. Thermometers and Psychrometric charts.

5. Determination of humidity- use of Dry Bulb and Wet Bulb.

6. Elementary Knowledge of Engineering Drawing- Concept of orthographic and isometric views of elevation and third angle projection. Notation and abbreviation used in Engineering drawing.

7. Basic Engineering Drawing Practice- Bolts, nuts, rivetted fronts, screws, worn screws as per specification.

8. Drawing of simple pharmaceutical machinery parts.

Pharmaceutical Chemistry - IV (B.Pharm Sem-III)

(Organic Chemistry - II)

Theory

Nucleophilic aromatic substitutions; α β unsaturated carbonyl compounds; Conservation of orbital symmetry and rules., Electrocyclic, Cycloaddition and sigmatropic reactions; Neighbouring group effects; Catalysis by transition metal complexes, Stereoselective and sterospecific reactions; New organic reagents used in drug synthesis.

Heterocyclic Compounds: Chemistry, preparations and properties of some important heterocyclic containing 3, 4,5,6 & 7 atoms with one or two heteroatoms like 0, N, S. Chemistry of lipids, Carbohydrates, Proteins and Nucleic acids.

Practicals

At least five exercises in synthesis involving various heterocyclic ring systems. An exercise involving stereoselective synthesis of a compound. Resolution of racemic DLalanine or any other example. Workshop on molecular modelling of primary, secondary, and tertiary structures of proteins, molecular modeling on the double-helical structure of nucleic acid showing hydrogen bonding.

Pharmacognosy - II (B.Pharm Sem-III)

Theory

1. Resins: Study of Drugs Containing Resins and Resin Combination like Colophony, podophyllum, jalap, cannabis, capsicum, myrrh, asafoetida, balsam of tolu, balsam of peru, benzoin, turmeric, ginger.

2. Tannis: Study of tannins and tannin-containing drugs like Gambir, black catechu, gall, and myrobalan.

3. Volatile Oils: General methods of obtaining volatile oils from plants, Study of volatile oils of Mentha, Coriander, Cinnamon, Cassia, Lemon peel, Orange peel, Lemongrass, Citronella, Caraway, Dill, Spearmint, Clove, Fennel, Nutmeg, Eucalyptus, Chenopodium, Cardamom, Valerian, Musk, Palmarosa, Gaultheria, Sandalwood.

4. Phytochemical Screening:

• Preparation of extracts.
• Screening of alkaloids, saponins, cardenolides, and bufadienolides, flavonoids and leucoanthocyanidins, tannins, and polyphenols, anthraquinone, cynogenetic glycosides, amino acids in plant extracts.

5. Fibres: Study of fibres used in pharmacy such as c0tton, silk, wool, nylon, glass wool, polyester and asbestos.

6. Pharmaceutical aids: Study of pharmaceutical aids like talc, diatomite, kaolin, bentonite, gelatin and natural colors.

Practicals

1. Identification of crude drugs mentioned in theory.

2. Study of fibres and pharmaceutical aids.

3. Microscopic studies of seven-selected crude drugs and their powders mentioned under the category of volatile oils in theory and their chemical tests,

4. General chemical tests for alkaloids, glycosides, steroids, flavonoids and tannins.

Pharmaceutical Analysis - II (B.Pharm Sem-III)

Theory

Theoretical considerations, and application in drug analysis and quality control of
the following analytical techniques

1. Non-aqueous titrations

2. Complexometric titrations

3. Miscellaneous Methods of Analysis: Diazotisation titrations, Kjeldahl method of nitrogen estimation, Karl-Fischer titration, Oxygen flask combustion, gasometry.

4. Extraction procedures including separation of drugs from excipients

5. Chromatography: The following techniques will be discussed with relevant examples of Pharmacopoeial products. TLC, HPLC, GLC, HPTLC, Paper Chromatography and Column Chromatography.

6. Potentiometry

7. Conductometry

8. Coulometry

9. Polarography

10. Amperometry

Practicals

1. Nonaqueous Titrations: Preparation and standardization of perchloric acid and sodium/potassium/lithium methoxides solutions; Estimations of some pharmacopoeial products.

2. Complexometric Titrations: Preparations and standardization of EDT A solution, some exercises related to pharmacopoeial assays by complexometric titrations.

3. Miscellaneous Determinations: Exercises involving diazotization, Kjeldahl, Karl Fischer, Oxygen flask combustion, and gasometry methods. Determination of alcohol content in liquid galenicals, procedure (BPC) shall be covered.

4. Experiments involving the separation of drugs from excipients.

5. Chromatographic analysis of some pharmaceutical products.

6. Exercises based on acid-base titration in aqueous and nonaqueous media, oxidation-reduction titrations using the potentiometric technique, Determination of acid-base disassociation constants, and plotting of titration curves using pH meter.

7. Exercises involving polarimetry.

8. Exercises involving conductometric and polarographic techniques.

Anatomy, Physiology and Health Education (B.Pharm Sem-III)

(APHE -II)

Theory

1. Digestive System: Gross anatomy of the gastro-intestinal tract, functions of its different parts including those of liver, pancreas, and gall bladder, various gastrointestinal secretions, and their role in the absorption and digestion of food. Disorders of the digestive system.

2. Respiratory System: Anatomy of respiratory organs & their functions, respiration, mechanism and regulation of respiration, respiratory volumes, and vital capacity.

3. Central Nervous System: Functions of different parts of the brain and spinal cord. Neurohumoral transmission in the central nervous system, reflex action electroencephalogram, specialized functions of the brain, Cranial nerves, and their functions.

4. Autonomic Nervous System: Physiology and functions of the autonomic nervous system. Mechanism of neurohumoral transmission in the A.N.S.

5. Urinary System: Various parts, structures, and functions of the kidney and urinary tract. Physiology of urine formation and acid-base balance. Diseases of the urinary system.

6. Reproductive System: Male and female reproductive systems and their hormones, physiology of menstruation, coitus, and fertilization. Sex differentiation, spermatogenesis & oogenesis. Pregnancy is maintenance and parturition.

7. Endocrine System: Basic anatomy and physiology of Pituitary, Thyroid, Parathyroid. Adrenals, Pancreas, tests, and ovary, their hormones and functions.

8. Sense Organs: Basic anatomy and physiology of the eye (vision), ear (hearing), taste buds, nose (smell), and skin (superficial receptors).

9. 

• Concepts of health and disease: Disease-causing agents and prevention of disease.

• Classification of food requirements: Balanced diet, nutritional deficiency disorders, their treatment and prevention, specifications for drinking water.

• Demography and family planning: Medical termination of pregnancy.

• Communicable diseases: Brief outline, their causative agents, modes of transmission, and prevention (Chickenpox, measles, influenza, diphtheria, whooping cough, tuberculosis, poliomyelitis, helminthiasis, malaria, filariasis, rabies, trachoma, tetanus, leprosy, syphilis, gonorrhea, and AIDS).

• First Aid: Emergency treatment of shock, snake bites, burns, poisoning, fractures, and resuscitation methods.

Practicals

1. Study of different systems with the help of charts and models.

2. Microscopic studies of different tissues.

3. Simple experiments involved in the analysis of normal and abnormal urine: Collection of specimen, appearance, determination of pH, Sugars, proteins, urea, and creatinine.

4. Physiological experiments on nerve-muscle preparations.

5. Determination of vital capacity, experiments on spirometry.

Pharmaceutics - III (B.Pharm Sem-IV)

Theory

(Unit Operations II)

1. Stoichiometry: Unit processes material and energy balances, molecular units, mole fraction, tie substance, gas laws, mole volume, primary and secondary quantities, equilibrium state, rate process, steady and unsteady states, dimensionless equations, dimensionless formulae, dimensionless groups, different types of graphic representation, mathematical problems.

2. Heat Transfer: Source of heat, heat transfer, steam, and electricity as heating media, determination of requirement of amount of steam/electrical energy, steam pressure, Boiler capacity, Mathematical problems on heat transfer.

3. Evaporation: Basic concept of phase equilibria, factor affecting evaporation, evaporators, film evaporators, single effect, and multiple effect evaporators, Mathematical problems on evaporation.

4. Distillation: Rault's law, phase diagrams, volatility; simple steam and flash distillations, principles of rectification, Mc. Cabe Thiele method for calculations of number of theoretical plates, Azeotropic and extractive distillation. Mathematical problems on distillation.

5. Drying: Moisture content and mechanism of drying, rate of drying and time of drying calculations; classification and types of dryers, dryers used in pharmaceutical industries.'1d special drying methods. Mathematical problems on drying.

6. Size Reduction and Size Separation: Definition, objectives of size reduction, factors affecting size reduction, laws governing energy and power requirements of a mill including ball mill, hammer mill, fluid energy mill, etc.

7. Mixing: Theory of mixing, solid-solid, solid-liquid, and liquid-liquid mixing equipment.

8. Automated Process Control Systems: Process variables, temperature, pressure, flow, level, and vacuum and their measurements. Elements of automatic process control and introduction to automatic process control systems. Elements of computer-aided manufacturing (CAM).

9. Reactors and fundamentals of reactors design for chemical reactions.

2.4.1. Practicals 4 hrs week
l. Determination of overall heat transfer coefficient.
2. Determination of rate of evaporation.
3. Experiments based on steam, extractive and azeotropic distillations.
4. Determination of rare of drying, free moisture content and bound moisture
content.
5. Experiments to illustrate the influence of various parameters on the rate of drying.
6. Experiments to illustrate principles of size reduction, Laws governing energy and
power requirements of size Reduction.
7. Experiments to illustrate solid-solid mixing, determination of mixing efficiency
using different types of mixers.
SEMESTER-IV
Pharmaceutical Microbiology
2.4.2. Theory 3 hrs /week
1. Introduction to the scope of microbiology.
2. Structure of bacterial cell.
3. Classification of microbes and their taxonomy. Actinomycetes, bacteria,
rickettsiae, spirochetes and viruses.
4. Identification of Microbes : Stains and types of staining techniques, electron
microscopy.
5. Nutrition, cultivation, isolation of bacteria, actinomycetes, fungi, viruses, etc.
6. Microbial genetics and variation.
7. Control of microbes by physical and chemical methods.
a. Disinfection, factors influencing disinfectants, dynamics of disinfection,
disinfectants and antiseptics and their evaluation.
b. Sterilization, different methods, validation of sterilization methods & equipments.
8. Sterility testing of all pharmaceutical products.
9. Immunity, primary and secondary, defensive mechanisms of body, microbial
resistance, interferon.
10. Microbial assays of antibiotics, vitamins & amino acids.
2.4.2. Practicals 4 hrs /week
Experiments devised to prepare various types of culture media, subculturing of common
aerobic and anaerobic bacteria, fungus and yeast, various staining methods, various
methods of isolation and identification of microbes, sterilization techniques and their
validation, evaluation of antiseptics and disinfectants, testing the sterility of
pharmaceutical products as per I.P. requirements, microbial assay of antibiotics and
vitamins, etc.
SEMESTER - IV
Pharmacognosy - III
2.4.3. Theory 3 hrs / week
1. Study of the biological sources, cultivation, collection, commercial varieties,
chemical constituents, substitutes, adulterants, uses, diagnostic macroscopic and
microscopic features and specific chemical tests of following groups of drugs
containing glycosides :
(i) Saponins : Liquorice, ginseng, dioscorea, sarsaparilla, and senega.
(ii) Cardioactive sterols: Digitalis, squill, strophanthus and thevetia.
(iii) Anthraquinone cathartics: Aloe, senna, rhubarb and cascara.
(iv) Others: Psoralea, Ammi majus, Ammi visnaga, gentian, saffron, chirata, quassia.
2. Studies of traditional drugs, common vernacular names, botanical sources,
morphology, chemical nature of chief constituents, pharmacology, categories and
common uses and marketed formulations of following indigenous drugs:
Amla, Kantkari, Satavari, Tylophora, Bhilawa, Kalijiri, Bach, Rasna, Punamava,
Chitrack, Apamarg, Gokhru, Shankhapushpi, Brahmi, Adusa, Atjuna, Ashoka,
Methi, Lahsun, Palash, Guggal, Gymnema, Shilajit, Nagarmotha and Neem.
3. The holistic concept of drug administration in traditional systems of medicine.
Introduction to ayurvedic preparations like Arishtas, Asvas, Gutikas, Tailas,
Chumas, Lehyas and Bhasmas.
2.4.3. Practicals 4 hrs / week
1. Identification of crude drugs listed in theory.
2. Microscopic study of some important glycoside containing crude drugs as
outlined above. Study of Powdered drugs.
3. Standardization of some traditional drug formulations.

SEMESTER - IV
Pathophysiology of Common Diseases

2.4.4 Theory 4 hrs week
1. Basic Principles of Cell Injury and Adaptation: Causes of Cellular injury,
pathogenesis, morphology of cell injury. Intercellular alterations in lipids, proteins
and carbohydrates, Cellular adaptation, atrophy, hypertrophy.
2. Basic Mechanisms involved in the process of inflammation and repair: Alterations
in vascular permeability and blood flow, migration of WBCS, acute and chronic
inflammation, mediators of inflammation, brief outline of the process of repair.
3. Pathophysiology of Common Diseases: Rheumatoid arthritis, gout, epilepsy,
psychosis, depression, mania, hypertension, angina, congestive heart failure,
atherosclerosis, myocardial infarction, diabetes, peptic ulcer, asthma, ulcerative
colitis, hepatic disorders, acute and chronic renal failure, tuberculosis, urinary
tract infections, sexually transmitted diseases, anemias and common types of
neoplasms. Wherever applicable the molecular basis should be discussed.
SEMESTER - IV
Pharmaceutics - IV
(Dispensing and Community Pharmacy)
2.4.5. Theory 3 hrs / week
1. Definition and Scope
2. Prescription: Handling of prescription, source of errors in prescription, care
required in dispensing procedures including labeling of dispensed products.
3. General dispensing procedures including labeling of dispensed products.
4. Pharmaceutical calculations: Posology, calculation of doses for infants, adults and
elderly patients; Enlarging and reducing recipes percentage solutions, allegation,
alcohol dilution, proof spirit, isotonic solutions, displacement value etc.
5. Principles involved and procedures adopted in dispensing of : Typical
prescriptions like mixtures, solutions, emulsions, creams, ointments, powders,
capsules, pastes, jellies, suppositories, opthalmics, pastilles, lozenges, pills,
lotions, liniments, inhalations, paints sprays tablet triturates, etc.
6. Incompatibilities: Physical and chemical incompatibilities, inorganic
incompatibilities including incompatibilities of metals and their salts, non-metals,
acids, alkalis, organic incompatibilities. Purine bases, alkaloids, pyrazolone
derivatives, amino acids, quaternary ammonium compounds, carbohydrates,
glycosides, anesthetics, dyes, surface active agents, correction of
incompatibilities. Therapeutic incompatibilities.
7. Community Pharmacy: Organization and structure of retail and whole sale drug
store-types of drug store and design, legal requirements for establishment,
maintenance and drug store-dispensing of proprietary products, maintenance of
records of retail and wholesale, patient counselling, role of pharmacist in
community health care and education.
2.4.5. Practicals 4 hrs / week
1. Dispensing of prescriptions falling under the categories : Mixtures, solutions,
emulsions. creams, ointments, powders, suppositories, opthalmics, capsules,
pastes, jellies, pastille, lozenges, pills, tablet triturates, lotions, liniments,
inhalations, paints, etc.
2. Identification of various types of incompatibilities in prescription, correction
thereof and dispensing of such prescriptions.
3. Dispensing procedures involving pharmaceuticals calculations, pricing of
prescriptions and dosage calculations for paediatric and geriatric patients.
4. Dispensing of prescriptions involving adjustment of tonicity.
5. Categorization and storage of pharmaceutical products based on legal
requirements of labelling and storage.
6. Project report on visit to the nearby Community for counselling on the rational
use of drugs and aspects of health care.
SEMESTER-V
Pharmaceutical Chemistry –V
(Biochemistry)
3.5.1. Theory 3 hrs / week
1. Biochemical organization of the cell and transport processes across cell
membrane.
2. The concept of free energy, determination of change in free energy - from
equilibrium constant and reduction potential, bioenergetics, production of A TP
and its biological significance.
3. Enzymes: Nomenclature, enzyme kinetics and its mechanism of action,
mechanism of inhibition, enzymes and iso-enzymes in clinical diagnosis.
4. Co-enzymes: Vitamins as co-enzymes and their significance. Metals as coenzymes and their significance.
5. Carbohydrate Metabolism: Conversion of polysaccharide to glucose-I-phosphate,
Glycolysis and fermentation and their regulation, Gluconeogenesis and
glycogenolysis, Metabolism of galactose and galactosemia, Role of sugar
nucleotides in biosynthesis, and Pentosephosphate pathway.
6. The Citric Acid Cycle: Significance, reactions and energetic of the cycle,
Amphibolic role of the cycle, and Glyoxalic acid cycle.
7. Lipids Metabolism : Oxidation of fatty acids, ~-oxidation & energetic, aoxidation, c.o-oxidation, Biosynthesis of ketone bodies and their utilization.
Biosynthesis of saturated anq unsaturated fatty acids, Control of lipid metabolism,
Essential fatty acids & eicosanoids (prostaglandins, thromboxanes and
leukotrienes), phospholipids, and sphingolipids.
8. Biological Oxidation : Redox-potential, enzymes and co-enzymes involved in
oxidation reduction & its control, The respiratory chain, its role in energy capture
and its control, Energetics of oxidative phosphorylation, Inhibitors of respiratory
chain and oxidative phosphoryla Mechanism of oxidative phosphorylation.
9. Nitrogen & Sulphur Cycle : Nitrogen fixation. ammonia assimilation, nitrification
and nitrate assimilation, Sulphate activation. sulphate reduction. Incorporation of
sulphur in organic compounds, Release of sulphur from organic compounds.
10. Metabolism of Ammonia and Nitrogen Containing Monomers : Nitrogen balance.
Biosynthesis of amino acids. Catabolism of amino acids. Conversion of amino
acids to specialized products, Assimilation of ammonia. Urea. cycle, metabolic
disorders of urea cycle. Metabolism of sulphur containing amino acids. Porphyrin
biosynthesis. formation of bile pigments. hyperbilirubinemia. Purine biosynthesis.
Purine nucleotide interconversion. Pyrimidine biosynthesis. and Formation of
deoxyribounucleotides.
11. Biosynthesis of Nucleic Acids: Brief introduction of genetic organization of the
mammalian genome, alteration and rearrangements of genetic material,
Biosynthesis of DNA and its replication. Mutation. Physical & chemical
mutagenesis / carcinogenesis. DNA repair mechanism. Biosynthesis of RNA.
12. Genetic Code and Protein Synthesis: Genetic code. Components of protein
synthesis. and Inhibition of protein synthesis. Brief account of genetic engineering
and polymerase chain reactions.
13. Regulation of gene expression.
3.5.1. Practicals 4 hrs / week
1. Preparation of standard buffers (citrate, phosphate and carbonate) and
measurement of pH.
2. Titration curve for amino acids.
3. Separation of amino acids by two dimensional paper chromatography and gel
electrophoresis.
4. The separation of lipids by TLC.
5. Separation of serum proteins by electrophoresis on cellulose acetate.
6. Quantitative estimation of amino acids.
7. Quantitative estimation of proteins.
8. The identification of c-terminal amino acids of a protein.
9 The determination of glucose by means of the enzyme glucose. oxidase.
10. The isolation and assay of glycogen from the liver and skeletal muscle of rats.
11 Enzymatic hydrolysis of glycogen by. alpha- and beta-amylases.
12. The isolation and determination of RNA and DNA.
13. Effect of temperature on the activity of alpha - amylase.
14. Estimation of SGOT, SGPT, ALP and BRN in the serum.
SEMESTER - V
Pharmaceutics - V
(Pharmaceutical Technology I)
3.5.2. Theory. 3 hrs / week
1. Liquid Dosages Forms: Introduction, types of additives used in formulations,
Vehicles, stabilizers, preservatives, suspending agents, emulsifying agents,
solubilizer, colors, flavours and others, manufacturing packaging and evaluation
of clear liquids, suspensions and emulsions official in pharmacopoeia.
2. Semisolid Dosage Forms: Definitions, types, mechanisms of drug penetration,
factors influencing penetration, semisolid bases and their selection. General
formulation of semisolids, clear gels manufacturing procedure, evaluation and
packaging.
3. Suppositories: Ideal requirements, bases, manufacturing procedure, packaging
and evaluation.
4. Extraction and Galenical Products : Principle and method of extraction,
preparation of infusion, tinctures, dry and soft liquid extracts.
5. Blood Products and Plasma Substitutes: Collection, processing and storage of
whole human blood, concentrated human RBCs, dried human plasma, human
fibrinogen, human thrombin, human normal immunoglobulin, human fibrin, foam
plasma substitutes, -ideal requirements, PVP, dextran etc. for control of blood
pressure as per I.P.
6. Pharmaceutical Aerosols : Definition, propellants, general formulation,
manufacturing' and packaging methods, pharmaceutical applications.
7. Ophthalmic Preparations: Requirements, formulation, methods of preparation,
containers, evaluation.
8. Cosmeticology and Cosmetic Preparations: Fundamentals of cosmetic science,
structure and functions of skin and hair. Formulation, preparation and packaging
of cosmetics for skin, hair, dentifrice and manicure preparations like nail polish,
Lipsticks, eye lashes, baby care products etc.
3.5.2. Practicals 4 hrs / week
1. Preparation, evaluation and packaging of liquid orals like solutions, suspensions
and emulsions, ointments, suppositories, aerosols, eye drops, eye ointments etc.
2. Preparation of pharmacopoeial extracts and galenical products utilizing various
methods of Extraction.
3. Collection, processing, storage and fractionation of blood.
4. Formulation of various types of cosmetics for skin, hair, dentifrices and manicure
preparations.
SEMESTER - V
Pharmacology I
3.5.3. Theory 3 hrs / week
1. General Pharmacology: Introduction to Pharmacology, Sources of drugs,
Dosage forms and routes of administration, mechanism of action, Combined
effect of drugs, Factors modifying drug action, tolerance and dependence,
Pharmacogenetics. Absorption, Distribution, Metabolism and Excretion of drugs,
Principles of Basic and Clinical pharmacokinetics, Adverse Drug Reactions and
treatment of poisoning, ADME drug interactions, Bioassay of Drugs and
Biological Standardization, Discovery and development of new drugs.
2. Pharmacology of Peripheral Nervous System:
a. Neurohumoral transmission (autonomic and Somatic)
b. Parasympathomimetics, Parasympatholytics, Sympathomimetics, Adrenergic
Receptor and neuron blocking agents, Ganglionic, stimulants and blocking agents.
c. Neuromuscular blocking Agents.
d. Local anesthetic Agents.
3. Pharmacology of Central Nervous System:
a) Neurohumoral transmission in the C.N.S.
b) General Anesthetics.
c) Alcohols and disulfiram.
d) Sedatives, hypnotics, Anti-anxiety agents and Centrally acting muscle relaxaQ.ts.
e) Psychopharmacological agents (anti-psychotics) antidepressants anti maniacs and
hallucinogens.
t) Anti-epileptics drugs.
g) Anti-Parkinsonian Drugs.
h) Analgesics, Antipyretics, Anti-inflammatory and Anti-gout drugs.
i) Narcotic analgesics and antagonists. J) C.N .S. stimulants
k) Drug Addiction and Drug Abuse.
3.5.3. Practicals 4 hrs / week
1. Introduction to Experimental Pharmacology :
Preparation of different solutions for experiments.
Drug dilutions, use of molar and w/v solutions in experimental pharmacology.
Common laboratory animals and anesthetics used in animal studies. Commonly
used instruments in experimental pharmacology. some common and standard
techniques.
Bleeding and intravenous injection, intragastric administration. Procedures for
rendering animals unconscious-stunning of rodents, pithing of frogs, chemical
euthanasia.
2. Experiments on intact preparations
Study of different routes of administration of drugs in mice/rats. To study the
effect of hepatic microsomal enzyme inhibitors and induction on the
pentobarbitone sleeping time in mice.
3. Experiments on Central Nervous system: Recording of spontaneous motor
activity, stereotypy, analgesia, anticonvulsant activity, anti- inflammatory
activity, and muscle relaxant activity of drugs using simple experiments. .
4. Effects of autonomic drugs on rabbit's eye.
5. Effects of various agonists and antagonists and their characterization using
isolated preparations like frog's rectus abdominis muscle " and isolated ileum
preparations of rat, guinea pig and rabbit.
SEMESTER - V
Pharmacognosy - IV
3.5.4. Theory 3 hrs / week 1.
1. Systematic study of source, cultivation, collection, processing, commercial
varieties, chemical constituents, substitutes, adulterants, uses, diagnostic
macroscopic and microscopic features and specific chemical tests of following
alkaloid containing drugs:
a) Pyridine - piperidine: Tobacco, areca and lobelia.
b) Tropane: Belladonna, hyoscyamus, datura, duboisia, coca and withania
c) Quinoline and isoquinoline : Cinchona, ipecac, opium.
d) Indole : Ergot, rauwolfia, catharanthus, nux-vomica and physostigma
e) Imidazole: Pilocarpus
f) Steroidal: Veratrum and kurchi
g) Alkaloidal amine: Ephedra and colchicum.
h) Glycoalkaloid: Solanum.
i) Purines: Coffee, tea and cola.
2. Role of medicinal and aromatic plants in national economy.
3. Biological sources, preparation, identification tests and uses of the following
enzymes: Diastase, papain, pepsin, trypsin, pancreatin.
4. General techniques of biosynthetic studies and basic metabolic pathways. Brief
introduction to biogenesis of secondary metabolites of pharmaceutical
importance.
5. Plant bitters and sweeteners.
6. Introduction, classification and study of different chromatographic methods and
their applications in evaluation of herbal drugs.
3.5.4. Practicals 4 hrs /week
i) Identification of crude drugs listed above.
ii) Microscopic study of characters of eight - selected drugs given in theory in entire
and powdered form.
iii) Chemical evaluation of powdered drugs and enzymes.
iv) Chromatographic studies of some herbal constituents.
SEMESTER - V
Pharmaceutics VI
(Hospital Pharmacy)
3.5.5. Theory 3 hrs / week
1. Organization and Structure : Organization of a hospital and hospital pharmacy,
Responsibilities of a hospital pharmacist, Pharmacy and therapeutic committee,
Budget preparation and Implementation.
2. Hospital Formulary : Contents, preparation and revision of hospital formulary.
3. Drug Store Management and Inventory Control:
(a) Organization of drug store, Types of materials stocked, storage conditions.
(b) Purchase and Inventory Control principles, purchase procedures, Purchase
order, Procurement and stocking.
4. Drug distribution Systems in Hospitals:
(a) Out-patient dispensing, methods adopted.
(b) Dispensing of drugs to in-patients. Types of drug distribution systems.
Charging policy, labeling.
(c) Dispensing of drugs to ambulatory patients.
(d) Dispensing of controlled drugs.
5. Central Sterile Supply Unit and their Management: Types of materials for
sterilization, Packing of materials prior to sterilization, sterilization equipments,
Supply of sterile materials.
6. Manufacture of Sterile and Nonsterile Products: Policy making of manufacturable
items, demand and costing, personnel requirements, manufacturing practice,
Master formula Card, production control, Manufacturing records.
7. Drug Information Services: Sources' of Information on drugs, disease, treatment
schedules, procurement qf information, Computerized services (e.g., MEDLINE),
Retrieval of information, Medication error.
8. Records and Reports: Prescription filling, drug profile, patient medication profile,
cases on drug interaction and adverse reactions, idiosyncratic cases etc.
9. Nuclear Pharmacy: Introduction to Radio- pharmaceuticals, radio-active halflife,
Units of radio-activity Production of radio-pharmaceuticals, methods of isotopic
tagging, preparation of radio-isotopes in laboratory using radiation dosimetry,
radio-isotope generators, Permissible radiation dose level, Radiation hazards and
their prevention, specifications for radio-active laboratory.
3.5.5 Practicals 4 hrs / week
1. Experiments based on sterilization of various types of materials used in
Hospitals.
2. Practicals designed on the use of computers in Drug Information Centre,
prescription filling, documentation of information on drug interaction.
3. Experiments to illustrate handling of radiopharma.ceutical products, measument
of radioactivity.
SEMESTER - VI
Pharmaceutical Chemistry - j[V
(Medicinal Chemistry - I)
3.6.1. Theory 3 hrs / week
1. Basic Principles of Medicinal Chemistry: Physico-chemical aspects (Optical,
geometric and bioisosterism) of drug molecules and bilological action, Drugreceptor interaction including transduction mechanisms.
2. Principles of Drug Design (Theoretic~fll Aspects) : Traditional analog (QSAR)
and mechanism based approaches (Introduction 00' graph theory, applications of
quantum mechanics, Computer Aided Drug Desigming (CADD) androolecular
modeling.
3. Synthetic procedures of selected drugs, mode of action, uses, structure activity
relationship including physicochemical properties of the following classes of
drugs:
A.Drugs acting at Synaptic and neuro-effector junction sites:
i. Cholinergics and Anticholinesterases
ii. Adrenergic .drugs
iii. Antispasmodic and anti ulcer drugs iv. Neuromuscular blocking agents.
B.Autocoids
i. Antihistamines ii. Eicosanoids
iii. Analgesic-antipyretics, anti-inflammatory (non-steroidal) agents.
C.Drugs affecting uterine motility
Oxytocics (including oxytocin, ergot alkaloids and prostaglandins' Biochemical
approaches in drug designing wherever applicable should be discussed.
3.6.1. Practicals 4 hrs /week
1. Exercises based on QSAR: Hansch & Free-Wilson methods.
2. Synthesis of selected drugs from the course content.
3. Spectral analysis of the drugs synthesized.
4. Establishing the pharmacopoeial standards of the drugs synthesized.
5. Determination of partition coefficient, dissociation constant and molar refractivity
of compounds for QSAR analysis.
SEMESTER - VI
Pharmaceutical Jurisprudence & Ethics
3.6.2. Theory 4 hrs /week
1. Introduction
a. Pharmaceutical Legislations - A brief review.
b. Drugs & Pharmaceutical Industry - A brief review.
c. Pharmaceutical Education - A briefreview.
2. An elaborate study of the following
a. Pharmaceutical Ethics
b. Pharmacy Act 1948.
c. Drugs and Cosmetics Act 1940 and Rules 1945.
d. Medicinal & Toilet Preparations (Excise Duties) Act 1955.
e. Narcotic Drugs & Psychotropic Substances Act 1985 & Rules.
f. Drugs Price Control Order.
3. A brief study of the following with special reference to the main provisions.
a. Poisons Act 1919
b. Drugs and Magic Remedies (Objectionable Advertisements) Act 1954
c. Medical Termination of Pregnancy Act 1970 & Rules 1975.
d. Prevention of Cruelty to Animals Act 1960.
e. States Shops & Establishments Act & Rules.
f. Insecticides Act 1968.
g. AICTE Act 1987.
h. Factories Act 1948.
j. Minimum Wages Act 1948. k Patents Act 1970.
4. A brief study of the various Prescription/Non-prescription Products, Medical
/Surgical accessories, Diagnostic aids, appliances available in the market.
Note: The teaching of all the about Acts should cover the latest amendments.
SEMESTER - VI
Pharmaceutics VII
(Biopharmaceutics & Pharmacokinetics)
3.6.3. Theory 3 hrs / week
1. Introduction to Biopharmaceutics and Pharmacokinetics and their role in
formulation development and clinical setting.
2. Biopharmaceutics
2.1. Passage of drugs across biological barrier (passive diffusion, active transport,
facilitated diffusion and pinocytosis).
2.2. Factors influencing absorption - Physicochemical, physiological and
pharmaceutical.
2.3. Drug distribution in the body, plasma protein binding.
3. Phamacokinetics :
3.1. Significance of plasma drug concentration measurement. 3.2. Compartment
model-Definition and Scope.
3.3. Pharmacokinetics of drug absorption - Zero order and first order absorption rate
constant using Wagner - Nelson and Loo- Reigelman method.
3.4. Volume of distribution and distribution coefficient.
3.5. Compartment kinetics - One compartment and two compartment models.
Determination of pharmacokinetic parameters from plasma and urine data after
drug administration by intravascular and o'al route.
3.6. Curve fitting (method of Residuals), regression procedures.
3.7. Clearance concept, Mechanism of renal clearance, clearance ratio, determination
of renal clearance.
3.8. Extraction ratio, hepatic clearance, biliary excretion, Extrahepatic circulation.
3.9. Non-linear pharmacokinetics with special reference to one compartment model
after 1. V drug administration, Michaeles Menten Equation, detection of nonlinearity (Saturation mechanism).
4. Clinical Pharmacokinetics: 4.1. Definition and scope
4.2. Dosage adjustment in patients with and without renal and hepatic failure.
4.3. Design of single dose bio-equivalence study and relevant statistics.
4.4. Pharmacokinetic drug interactions and their significance in combination therapy.
5. Bioavailability and bioequivalence :
5.1. Measures of bioavailability, Cmax, t max, and Area Under the Curve (AUe).
5.2. Design of single dose bioequivalence study and relevant statistics.
5.3. Review of regulatory requirements for conduction of bioequivalent studies.
3.6.3. Practicals 4hrs / week
1. Experiments designed for the estimation of various pharmacokinetic parameters
with given data.
2. Analysis of biological specifications for drug content and estimation of the
pharmacokinetic parameters.
3. In vitro evaluation of different dosage forms for drug release.
4. Absorption studies - in- vitro and in -situ.
5. Statistical treatment of pharmaceutical data.
SEMESTER-VI
Pharmacology - II
3.6.4. Theory 4 hrs week
1. Pharmacology of Cardiovascular System:
a) Digitalis and cardiac glycosides.
b) Antihypertensive drugs.
c) Antianginal and Vasodilator drugs, including calcium channel blockers and beta
adrenergic antagonists.
d) Antiarrhythmic drugs
e) Antihyperlipedemic drugs
f) Drugs used in the therapy of shock.
2 Drugs Acting on the Hemopoietic System:
a) Hematinics.
b) Anticoagulants, Vitamin K and hemostatic agents.
c) Fibrinolytic and anti-platelet drugs.
d) Blood and plasma volume expanders.
3. Drugs acting on urinary system:
a) Fluid and electrolyte balance
b) Diuretics
4. Autocoids :
a) Histamine, 5-HT and their antagonists.
b) Prostaglandins, thromboxanes and leukotrienes.
c) Pentagastrin, Cholecystokinin, Angiotensin, Bradykinin and Substance P.
5. Drugs Acting on the Respiratory System:
a) Anti-asthmatic drugs including bronchodilators.
b) Anti-tussives and expectorants.
c) Respiratory stimulants.
3.6.4. Practicals 6 hrs / week
1. Experiments on Isolated Preparations:
a) To record the concentration response curve (CRC) of acetylcholine using rectus
abdominis muscle preparation of frog.
b) To study the effects of physostigmine and d-tubocurarine on the CRC of
acetylcholine using rectus abdominis muscle preparation of frog.
c) To record the CRC of 5-HT on rat fundus preparation.
d) To record the CRC of histamine on guinea pig ileum preparation.
e) To record the CRC of noraderenaline on rat anococcygeus muscle preparation.
f) To record the CRC of oxytocin using rat uterus preparation.
2. Pharmacology of Cardiovascular System:
a) To study the ionotropic and chronotropic effects of drugs on isolated frog heart.
b) To study the effects of drugs on normal and hypodynamic frog heart.
3. Blood Pressure of anaesthetized Dog/Cat/Rat :
To demonstrate the effects of various drugs on the B.P. and respiration including
the Vasomotor Reversal of Dale and nicotinic action of acetylcholine.
SEMESTER - VII
Pharmacognosy - V
(Chemistry of Natural Products)
3.6.5. Theory 3 hrs / week
1. Chemical and spectral approaches to simple molecules of natural origin
2. Concept of stereoisomerism taking examples of natural products.
3. Chemistry, biogenesis and pharmacological activity of medicinally important
monoterpenes, sesquiterpenes, diterpenes, and triterpenoids.
4. Carotenoids: α-carotenoids, β-carotenes, vitamin A, Xanthophylls of medicinal
importance.
5. Glycosides : Chemistry and biosynthesis of digitoxin, digoxin, hecogenin,
sennosides, diosgenin and sarasapogenin.
6. Alkaloids: Chemistry, biogenesis and pharmacological activity of atropine and
related compounds; quinine, reserpine, morphine, papaverine, ephedrine, ergot
and vinca alkaloids.
7. Chemistry and biogenesis of medicinally important lignans and quassanoids,
flavonoids.
8. Chemistry and therapeutic activity of penicillin, streptomycin and tetracyclines.
3.6.5. Practicals 4 hrs / week
i) Laboratory experiments on isolation, separation, purification of various groups of
chemical constituents of pharmaceMtical significance.
ii) Exercises on paper and thin layer chromatographic evaluations of herbal drug
constituents.
SEMESTER - VII
Pharmaceutical Biotechnology
4.7.1. Theory 4 hrs /week
1. Immunology and Immunological Preparations : Principles, antigens and
haptens, immune system, cellular humorai immunity, immunological tolerance,
antigen-antibody reactions and their applications. Hypersensitivity, Active and
passive immunization; Vaccines- their preparation, standardization and storage.
2. Genetic Recombination : Transformation, conjugation, transduction, protoplast
fusion and gene cloning and their applications. Development of hybrid om a for
monoclonal antibodies. Study of drugs produced by biotechnology such as
Activase, Humulin, Humatrope, HB etc.
3. Antibiotics: Historical development of antibiotics. Antimicrobial spectrum and
methods used for their standardization. Screening of soil for organisms producing
antibiotics, fermenter, its design, control of different parameters. Isolation of
mutants, factors influencing rate of mutation. Design of fermentation process.
Isolation of fermentation products with special reference to penicillins,
streptomycins tetracyclines and vitamin B12•
4. Microbial Transformation : Introduction, types of reactions mediated by
microorganisms, design of biotransformation processes, selection of organisms,
biotransformation process and its improvements with special reference to steroids.
5. Enzyme immobilization: Techniqes of immobilization, factors affecting enzyme
kinetics. Study of enzymes such as hyaluronidase, penicillinase, streptokinase and
streptodornase, amylases and proteases etc. Immobilization of bacteria and plant
cells.

Pharmaceutics - VIII (B.Pharm Sem-VII)

Theory

1. Capsules: Advantages and disadvantages of capsule dosage form, material for the production of hard gelatin capsules, size of capsules, method of capsule filling, soft gelatin, capsule shell and capsule content, the importance of base absorption, and minimum/gm factors in soft capsules, quality control, stability testing, and storage of capsule dosage forms.

2. Microencapsulation: Types of microcapsules, the importance of microencapsulation in pharmacy, microencapsulation by phase separation, coacervation, multi orifice, spray drying, spray congealing, polymerization complex emulsion, air suspension technique, coating pan, and other techniques, evaluation of microcapsules.

3. Tablets:
a) Formulation of different types of tablets, granulation, technology on large-scale by various techniques, physics of tablet making, different types of tablet compression machinery and the equipment employed, evaluation of tablets.

b) Coating of Tablets: Types of coating, film-forming materials, formulation of the coating solution, equipment for coating, coating process, evaluation of coated tablets.

c) Stability kinetics and quality assurance.

4. Parenteral Products:

a) Preformulation factors, routes of administration, water for injection, pyrogenicity, nonaqueous vehicles, isotonicity, and methods of its adjustment

b) Formulation details, containers and closures, and selection.

c) Prefilling treatment, washing of containers and closures, preparation of solution and suspensions, filling, and closing of ampoules, vials, infusion fluids, lyophilization & preparation of sterile powders, equipment for large scale manufacture and evaluation of parenteral products.

d) Aseptic Techniques-source of contamination and methods of prevention, Design of aseptic area, Laminar flow bench services, and maintenance.

e) Sterility testing of pharmaceuticals.

5. Surgical products: Definition, primary wound dressing, absorbents, surgical cotton, surgical gauzes, etc., bandages, adhesive tape, protective cellulosic hemostatic, official dressings, absorbable and nonabsorbable sutures, ligatures, and catguts. Medical prosthetics and organ replacement materials.

6. Packaging of Pharmaceutical Products: Packaging components, types, specifications and methods of evaluation, stability aspects of packaging.Packaging equipment, factors influencing the choice of containers, legal and other official requirements for containers, package testing.

Practicals

1. Experiments to illustrate preparation, stabilization, physical and biological evaluation of pharmaceutical products like powders, capsules, tablets, parenteral, microcapsules, surgical dressing, etc.
2. Evaluation of materials used in pharmaceutical packaging.

Pharmaceutical Industrial Management (B.Pharm Sem-VII)

Theory:

1. Concept of Management: Administrative Management (Planning, Organizing, Staffing, Directing and Controlling), Entrepreneurship development, Operative Management (Personnel, Materials, Production, Financial, Marketing, Time/space, Margin/Morale). Principles of Management (Co-ordination, Communication, Motivation, Decision-making, leadership, Innovation, Creativity, Delegation of Authority / Responsibility, Record Keeping). Identification of key points to give maximum thrust for development and perfection.

2. Accountancy: Principles of Accountancy, Ledger posting, and book entries, preparation of trial balance, columns of a cash book, Bank reconciliation statement, the rectification of errors, Profits and loss account, balance sheet, purchase, keeping, and pricing of stocks, treatment of cheques, bills of exchange, promissory notes and hundies, documentary bills.

3. Economics: Principles of economics with special reference to the laws of demand and supply, demand schedule, demand curves, labor welfare, general principles of insurance and inland and foreign trade, the procedure of exporting and importing goods.

4. Pharmaceutical Marketing: Functions, buying, selling, transportation, storage, finance, feedback, information, channels of distribution, wholesale, retail, departmental store, multiple shops, and mail order businesses.

5. Salesmanship: Principles of sales promotion, advertising, ethics of sales, merchandising, literature, detailing. Recruitment, training, evaluation, compensation to the pharmacist.

6. Market Research:

(a) Measuring & Forecasting Market Demands-Major concept in demand measurement, Estimating current demand, Geodemographic analysis, Estimating industry sales, Market share & Future demand.

(b) Market Segmentation & Market Targeting.

7. Materials Management: A brief exposure or basic principles of materials management-major areas, scope, purchase, stores, inventory control, and evaluation of materials management.

8. Production Management: A brief exposure of the different aspects of Production Management-Visible and Invisible inputs, Methodology of Activities, Performance Evaluation Technique, Process-Flow, Process know-how, Maintenance Management.

Pharmacology - III (B.Pharm Sem-VII)

Theory:

1.Drugs Acting on the Gastrointestinal Tract:

(a) Antacids, Anti Secretory, and Anti-ulcer drugs.
(b) Laxatives and antidiarrhoeal drugs.
(c) Appetite Stimulants and Suppressants

(d) Emetics and anti-emetics.
(e) Miscellaneous-Carminatives, demulcents, protectives, adsorbents, astringents, digestants, enzymes, and mucolytics.

2.Pharmacology of Endocrine System:

(a) Hypothalamic and pituitary hormones
(b) Thyroid hormones and antithyroid drugs, parathormone, calcitonin, and Vitamin D.
(c) Insulin, oral hypoglycaemic agents & glucagon.
(d) ACTH and corticosteroids.
(e) Androgens and anabolic steroids.
(f) Estrogens, progesterone, and oral contraceptives.

(g) Drugs acting on the uterus.

3.Chemotherapy:
(a) General Principles of Chemotherapy.

(b) Sulfonamides and cotrimoxazole.
(c) Antibiotics-Penicillins, Cephalosporins, Chloramphenicol Erythromycin, Quinolones, and Miscellaneous Antibiotics.
(d) Chemotherapy of tuberculosis, leprosy, fungal diseases, viral diseases, urinary tract infections, and sexually transmitted diseases.
(e) Chemotherapy of malignancy and Immunosuppressive Agents.

4.Principles of Toxicology:
(a) Definition of poison, general principles of treatment of poisoning with particular reference to barbiturates, opioids, organophosphorus, and atropine poisoning.
(b) Heavy metals and heavy metal antagonists.

Practicals

1. Experiments on Isolated Preparations:

(a) To calculate the pA2 value of atropine using acetylcholine as an agonist on rat ileum preparation.
(b) To calculate the pA2 value of mepyramine or chlorpheniramine using
histamine as an agonist on guinea-pig ileum.
(c) To estimate the strength of the test sample of agonist/drug (e.g. Acetylcholine,
Histamine, 5 -HT, Oxytocin, etc) using a suitable isolated muscle preparation
employing Matching bioassay, Bracketing assay, Three-point assay, and Four-point bioassay.

2. Pharmacology of the Gastrointestinal Tract: To study the Anti- secretary and anti-ulcer activity using pylorus.

3. Clinical pharmacology: To determine the effects of certain clinically useful drugs on human volunteers like:
(a) Antihistaminics
(b) Anti-anxiety and sedative drugs (c) Analgesics
(d) Beta-blockers.

Medicinal Chemistry - II (B.Pharm Sem-VII)

Theory

Synthetic procedures of selected drugs, mode of action, use structure-activity relationship including Physico-Chemical properties of the following classes of drugs.

1. Steroids and related drugs: Steroidal nomenclature and stereochemistry, androgens and anabolic agents, estrogens, and progestational agents, adrenocorticoids.

2. Drugs acting on the Central Nervous System: General Anesthetics, Local Anesthetics, Hypnotics, and Sedatives, Opioid analgesics, antitussives, anticonvulsants, Antiparkinsonism drugs, CNS stimulants, Psychopharmacological agents (neuroleptics, antidepressants, anxiolytics).

3. Diuretics, Cardiovascular drugs, Anticoagulants, and Antiplatelet drugs. Biochemical approaches in drug designing wherever applicable should be discussed.

Practicals

1. Workshop on stereo model use of some selected drugs.
2. Synthesis of selected drugs from the course content involving two or more steps and their spectral analysis.
3. Establishing the Pharmacopoeial standards of the drugs synthesized.

Pharmaceutics IX (Dosage Form Design) (B.Pharm Sem-VIII)

Theory

1. Preformulation studies:

a) Study of physical properties of drug-like physical form, particle size, shape, density, wetting dielectric constant. Solubility, dissolution, and organoleptic property and their effect on formulation, stability, and bioavailability.

b) Study of chemical properties of drugs like hydrolysis, oxidation, reduction, racemization, polymerization, etc., and their influence on formulation and stability of products.

c) Study of pro-drugs in solving problems related to stability, bioavailability
and elegancy of formulations.

2. Design, development, and process validation methods for pharmaceutical operations involved in the production of pharmaceutical products with special reference to tablets, suspensions.

3. Stabilization and stability testing protocol for various pharmaceutical products.

4. Performance evaluation methods
a) In-vitro dissolution studies for solid dosage forms methods, interpretation of dissolution data.
b) Bioavailability studies and bioavailability testing protocol and procedures.
c) In-vivo methods of evaluation and statistical treatment.

5. GMP and quality assurance, Quality audit

6. Design, development, production, and evaluation of controlled released formulations.

Practicals

1. Preformulation studies including drug-excipient compatibility studies, the effect of stabilizers, preservatives, etc. in dosage form design.

2. Experiments demonstrating improvement in bioavailability through prodrug concept.

3. Stability evaluation of various dosage forms and their expiration dating.

4. Dissolution testing and data evaluation for oral solid dosage forms.

6. In -vivo bioavailability evaluation from plasma drug concentration and urinary excretion curves.

7. Design, development, and evaluation of controlled release formulations.

Pharmaceutical Analysis -III (B.Pharm Sem-VIII)

Theory

A. Quality assurance:

1. GLP, ISO 9000, TQM, Quality Review, and Quality Documentation.
2. Regulatory control, regulatory drug analysis, interpretation of analytical data.
3. Validation, quality audit: quality of equipment, validation of equipment, validation of analytical procedures.

B. The theoretical aspects, basic instrumentation, elements of interpretation of spectra, and applications of the following analytical techniques should be discussed:

1. Ultraviolet and visible spectrophotometry
2. Fluorimetry.
3. Infrared spectrophotometry.
4. Nuclear Magnetic Resonance spectroscopy including 13c NMR.
5. Mass Spectrometry.
6. Flame Photometry.
7. Emission Spectroscopy.
8. Atomic Absorption Spectroscopy.
9. X-ray Diffraction. 10. Radioimmunoassay.

Practicals

1. Quantitative estimation of at least ten formulations containing a single drug or more than one drug, using instrumental techniques.

2. Estimation of Na+, K+, Ca++ ions using flame photometry.

3. IR of samples with different functional groups (-COOH, -COOR. _ CONHR; - NH2, -NHR, -OH, etc.).

4. Workshop to interpret the structure of simple organic compounds using UV, IR. NMR and MS.

Medicinal Chemistry III (B.Pharm Sem-VIII)

Theory

1. Drug metabolism and Concepts of Prodrugs.

2 Synthetic procedures of selected drugs, mode of action, use, structure-activity relationship (including physicochemical aspects) of the following classes of drugs. (Biochemical approaches in drug designing wherever applicable should be discussed).

i) Antimetabolites (including sulfonamides).
ii) Chemotherapeutic agents used in Protozoal, Parasitic, and other infection
iii) Antineoplastic agents
iv Anti-viral including anti - HIVagents.
v) Immunosuppressives and immunostimulants.

3. Amino acids, peptides, nucleotides, and related drugs.

a. Thyroid and Antithyroid drugs
b. Insulin and oral hypoglycaemic agents.
c. Peptidomimetics and nucleotidomimetics.
vi. Diagnostic agents.
vii. Pharmaceutical Aids.

Practicals

1. Experiments designed on drug metabolism:

a. Preparation of S9 and microsomes from tissue homogenates and standardization of protein.
b. Effect of phenobarbital pretreatment on microsomal cytochrome p-450, cytochrome b5, and NADPH-Cytochrome C-reductase and comparison of microsomes from control.
c. Determination of microsomal aminopyrine demethylase and p_ nitro anisole demethylase activities.
d. Determination of microsomal azo- and nitroreductase activities.

2. Synthesis of selected drugs.

3. Establishing the pharmacopoeial standards and spectral studies.

Pharmacognosy – VI (B.Pharm Sem-VIII)

Theory

1. World-wide trade in medicinal plants and derived products with special reference
to diosgenin (Dioscorea), taxol (Taxus sps) digitalis, tropane alkaloid containing
plants, Papain, cinchona, Ipecac, Liquorice, Ginseng, Aloe, Valerian, Rauwolfia
and plants containing laxatives.

2. A brief account of plant-based industries and institutions involved in work on medicinal and aromatic plants in India. Utilization and production of phytoconstituents such as quinine, calcium sennosides, podophyllotoxin, diosgenin, solasodine, and tropane alkaloids.

3. Utilization of aromatic plants and derived products with special reference to sandalwood oil, mentha oil, lemongrass oil, vetiver oil, geranium oil, and eucalyptus oil.

4. Historical development of plant tissue culture, types of cultures,. nutritional requirements, growth, and maintenance. Applications of plant tissue culture in pharmacognosy.

5. Chemotaxonomy of medicinal plants.

6. Marine pharmacognosy, novel medicinal agents from marine sources.

7. Natural allergens and photosensitizing agents and fungal toxins.

8. Herbs as health foods.

9. Herbal cosmetics.

Practicals

(i) Isolation of some selected phytoconstituents studied in theory.
(ii) Extraction of volatile oils and their chromatographic profiles.
(iii) Some experiments in plant tissue culture.

Clinical Pharmacy and Drug Interactions (B.Pharm Sem-VIII)

Theory

1.Introduction to Clinical Pharmacy.

2.Basic Concepts of Pharmacotherapy.
a) Clinical Pharmacokinetics and individualization of Drug Therapy.
b) Drug Delivery Systems and their Biopharmaceutic & Therapeutic
Considerations.
c) Drug Use During Infancy and in the Elderly (Pediatries & Geriatrics).
d) Drug use during Pregnancy.
c) Drug induced Diseases.
d) The Basics of Drug Interactions.
g) General Principles of Clinical Toxicology"
h) Interpretation of Clinical Laboratory Tests.

3. Important Disorders of Organ Systems and their Management:
a) Cardiovascular Disorders-Hypertension, Congestive Heart Failure, Angina,
Acute Myocardial Infarction, Cardiac arrhythmias.
b) CNS Disorders: Epilepsy, Parkinsonism, Schizophrenia, Depression.
c) Respiratory Disease-Asthma.
d) Gastrointestinal Disorders-Peptic ulcer, Ulcerative colitis, Hepatitis,
Cirrhosis.
c) Endocrine Disorders-Diabetes mellitus and Thyroid Disorders. t) Infectious
Diseases-Tuberculosis, Urinary Tract Infection, Enteric Infections, Upper
Respiratory Infections.
g) Hematopoietic Disorders-Anemias.
h) Joint and Connective Tissue Disorders-Rheumatic Diseases, Gout and
Hyperuricemia.
i) Neoplastic Diseases- Acute Leukaemias, Hodgkin's disease.

4. Therapeutic Drug Monitoring

5. Concept of Essential Drugs and Rational Drug use.

4.8.6. Project Related to Elective 4 hrs / week
Proposed List of Elective Subjects
in Semester – VII
1. Pharmaceutical marketing
2. Medicinal plant biotechnology
3. Quality assurance
4. Drug design and lead identification
5. Bioavailability and therapeutic drug monitoring
6. Cosmeticology
7. Packaging technology
8. Any other emerging area availing the local expertise
MODEL ACADEMIC PROGRAMME AND
EVALUATION SCHEME
B. PHARM SEMESTER
(Structure of Courses)
Note: It is desired that 80% course contents from the above structure is adhered to in
order to maintain uniformity.
Subject *L+T P
Semester 1
1.1.1. Pharmaceutical Analysis - I 3 4
1.1.2. Remedial Mathematics/Biology 4/3 0/4
1.1.3. Phannacognosy- I 3 4
1.1.4. Pharmaceutical Chemistry - I 3 4
(Inorganic Pharmaceutical
Chemistry)
1.1.5. Basic Electronics & 3 4
Computer Applications
16/15 16/20
Semester II
1.2.1. Pharmaceutics - I 3 4
(Physical Pharmacy)
1.2.2. Advanced Mathematics 4 _
1.2.3. Pharmaceutical Chemistry-II 3 4
(Physical Chemistry)
1.2.4. Pharmaceutical Chemistry-III 4 6
(Organic Chemistry - I)
1.2.5. Anatomy Physiology & Health 3 4
Education (APHE I) - I
17 18
* L - Lecture T - Tutorial P - Practical
Semester III
2.3.1. Pharmaceutics - II (Unit
Operations -I, including Engg. 3 4
Drawing)
2.3.2. Pharmaceutical Chemistry - IV 3 4
(Organic Chemistry - II
2.3.3. Pharmacognosy - II 3 4
2.3.4. Pharmaceutical Analysis -II 3 4
2.3.5. A P H E - II 3 4
15 20
Semester IV
- 2.4.1 Pharmaceutics - III
(Unit Operations - II) 3 4
2.4.2. Pharmaceutical Microbiology 3 4
2.4.3. Pharmacognosy - III 3 4
2.4.4. Pathophysiology of Common 4-
Diseases
2.4.5. Pharmaceutics - IV 3 4 _
(Dispensing & Community Pharmacy)
16 16
Semester V
3.5.1. Pharmaceutical Chemistry V
(Biochemistry) 3 4
3.5.2. Pharmaceutics - V
(Pharmaceutical Technology I) 3 4
3.5.3. Pharmacology -I 3 4
3.5.4. Pharmacognosy - IV .. - 3 4
3.5.5. Pharmaceutics - VI 3 4
(Hospital pharmacy)
15 20
Semester VI
3.6.1. Pharmaceutical Chemistry - VI 3 4
(Medicinal Chemistry-I) 4-
3.6.2. Pharmaceutical Jurisprudence
& Ethics
3.6.3. Pharmaceutics - VII 3 4
(Biopharmaceutics & Pharmacokinetics)
3.6.4. Pharmacology - II 4 6
3.6.5. Pharmacognosy - V 3 4
(Chemistry of Natural Products)
17 18·
Compulsory Industrial Training of Four Weeks with Component of Evaluation after
Completion of VI Semester
Semester VII
4.7.1. Pharmaceutical 4-
Biotechnology
4.7.2. Pharmaceutics VIII 4 6
(Pharmaceutical Technology II)
4.7.3. Pharmaceutical Industrial 4-
Management
4.7.4. Pharmacology III 3 4
4.7.5. Pharmaceutical Chemistry VII 3 4
(Medicinal Chemistry II)
4.7.6. Elective (Theory) 4-
22 14
Semester VIII
4.8.1. Pharmaceutics IX 3 3
4.8.2. Pharmaceutical Analysis III 3 6
4.8.3. Pharmaceutical Chemistry VIII 3 3
(Medicinal Chemistry - III)
4.8.4. Pharmacognosy VI 3 3
4.8.5. Pharmacology N 4-
(Clinical Pharmacy & Drug Interactions)
4.8.6. Project related to - 4
Elective
16 19
1 Each Semester will consist of a minimum of 15 weeks instructions.
*i.e. 15x6 = 90 instructional days (Actual teaching).
2. There will be a minimum of one sessional examination of 20 marks in each of the
theory subjects during each semester. There will be no separate sessional
examination in practicals.
3. Internal assessment of practicals (20%) will be based on day to day attendance.
viva, laboratory record, etc. The question papers of university examinations shall
be set by one or more external examiners. The choice in question papers shall be
restricted to 25% only. Complete coverage of prescribed syllabus in university
question papers is desired.
4. 20% marks shall be allotted for sessional examinations in theory. A minimum of
75% attendance in theory and practical classes is compulsory.
5. In view of the fact that B. Pharm is a professional degree with diverse
employment potential, the university degree certificate may continue to remain
the same with no mention of elective subjects. However, the mark-list should
indicate the elective/s opted by the candidate.
BOOK RECOMMENDED
IT IS UNDERSTOOD THAT THE TEACHER WOULD FOLLOW AND
RECOMMEND LATEST EDITION OF THE' BOOK, HENCE THE SPECIFIC
EDITION AND YEARS OF PUBLICATION ARE OMITTED.
1. PHARMACEUTICS
(Pharmaceutical Technology" Dispensing Pharmacy,
Forsenic Pharmacy and Pharmaceutical Microbiology)
A Owunwonne, Handbook of Radiopharmaceuticals, Narosa Publishing House, New
Delhi.
A Pecile and A ResignoPharmacokinetics, Plenum Press, NY.
Aiba Suichi, Humphrey and Millis, Biochemical Engineering, University of Tokyo Press.
Allwodd M C and Fell J T, Textbook of Hospital Pharmacy, Blackwell Scientific
Publications, Oxford.
Ansel H C, Introduction to Pharmaceutical Dosage Forms, K M Varghese & Co.,
Bombay.
Aulton M E Pharmaceutics - The Science of Dosage Form Design, ELBS/ Churchill
Livingstone.
Avis K E, Lachman L and Licberman H A, Marcel Dekker Inc. Pharmaceutical Dosage
Forms; Parenteral Medications, Vols. 1& 2, NY.
Badger W L and Banchero J T, Introduction to Chemical Engineering McGraw Hill
Intematonal Book Co.,London.
Banker G S and Rhode C T Modem Pharmaceutics, Marcel Dekker Inc., NY.
Bean H S, Beckett A H, and Carless A H Advances in Pharmaceutical Sciences, Vol 1-4
Academic Press, London.
Bergey's Manual of Determinative bacteriology.
Bharati H K, Drugs and Pharmacy Laws in India, Sadhana Mandir, Indore.
Bolton Sanford, Pharmaceutical Statistics, Mareel Dekker inc NY.
British .National Formulary, No. 25 Pub jointly by British Medical Association and
Royal Pharmaceutical Society of Great Britain.
British Pharinacopoiea, Her Majesty's Stationery office, University Press, Cambridge.
Brock T D, Madigen M T Biology of Micro-organism Prentice Hall, New Jersey USA.
Carter S. 1. Cooper and Gunn's Dispensing for Pharmaceutical Students, CBS Publishers,
Delhi.
Carter S J, Cooper and Gunn's Tutorial Pharmacy CBS Publishers, Delhi.
Cartstensen J T, Drug Stability, Marcel Dekker Inc NY.
Chittion H M and witcofski R L, Nuclear pharmacy Lea and Febiger, Philadelphia.
Connores KA, Amiden GLand Stella V J, Chemical Stability of Pharmaceuticals, John
Wiley & Sons NY.
Dittert L W Sprowl's Smerican Pharmacy, J & B Lippincott Co., Philadelphia.
C G Brown, Unit Operatons (Indian ed) Asia Publishing House, Bombay. Gibaldi M &
Perrier D, Pharmacokinetics, Marcel Dekker Inc NY.
Remington's The science and Practice of Pharmacy, Mack Publishing Co. Easton,
Pernsybrania.
Hassan William E, Hospital Pharmacy, Lea & Febiger, Philadelphia.
Hoover J E Dispensing of Medication, ed Mack Publishing Co., Easton P A.
Hugo and Russel, Pharmaceutical Microbiology; Blackwell Scientific Publication,
Oxford.
Jellinek J S, Formulation and Function of Cosmetics, John Wiley & Sons, NY.
Jain N K A Text Book of Forsenic Pharmacy, Vallabh Prakashan, Delhi.
Juliano R L, Drug Delivery Systems, Oxford University Press, Oxford.
KacChensney J C Packaging of Cosmetics and Toiletories, Newness Butterworth,
London.
Kielslich K, Ed Biotechnology vol6a, Verleg Chemie, Switzerland.
Lachmen L, Lieberman HA and Kanig J L, The Theory and Practice of Industrial
Pharmacy, Lea & Febiger, Philadelphia.
Lea & Fibiger "Milo Gibaldi, Biopharmaceutics & Clinical Pharmacokinetics",
Philadelphia.
Lea and Febiger Pharmaceutical Dosage. Forms and Drug Delivery Systems,
Philadelphia.
Lewin Benjamin, Gene V Microbiology.
Liberman H A. Rieger M M and Banker G 8, "Pharmaceutical Dosage Forms; Dispense
Systems, Vols. 1 &2, Marcel Dekker Inc., NY.
Lieberman H A, Lachman L & Schwartz J B Pharmaceutical Dosage Forms.: Tablets,
'Vols. 1-3, Marcel Dekker Inc., NY.
Loftus B T and Nash Robert, Pharmaceutical Process Validation, Marcel Dekker inc.,
NY.
MaCabe W L and Smith j. C, Unit Operations of Chemical Engineering McGraw Hill
International Book Co., London.
Martin A N, Arthur Cammarata, James Swarbrick, Physical Pharmacy, K M Varghese &
Co., Bombay.
Martin E. W. Dispensing of Medication, Mack Publishing Co., Eastern P A.
Martindale: The Extra Pharmacopoiea, ed J E F Reynolds, The Pharmaceutical Press,
London.
Merchant H.S and Qadry J. S, Text Book of Hospital Pharmacy, B.S. Shah Prakashan,
Ahmedabad.
Mittal B.M. A Text Book of Forsenic Pharmacy, National Book Depot, Calcutta.
Notari R E, Biopharmaceutis and Pharmacokinetics - an Introduction Marcel Dekker Inc
NY.
Parry R H & Chilton C H Chemical Engineers Handbok, McGraw Kogakusha Ltd.
Peppier, Microbial Technology, vol l & II.
Pharmacopoiea of India, published by the Controller of Publications, Delhi, I st ed -
1966- 1985 4th ed- 1996.
Prescott L M, Jarely G P, Klein D A, Microbiology, Wm C Borown Publishers, Oxford.
Prescott and Dunn, Industrial Microbiology, McGraw Hill Book Company Inc.
Rawlins EA Bentley's Textbook of Pharmaceutics ELBS Bacilliere Tindall.
Ridgway K Hard Capsules, The Pharmaceutical Press, London.
Ritschel W A, Handbook of Basic Pharmacokinetics, Drug Intelligence Publications,
Hamilton.
Robinson J R & Lee Vincent, Controlled Drug Delivery: Fundamentals & Applications,
Marcel Dekker Inc., NY.
Rowland M. and Tozer T. N., Clinical Pharmacokinetics, Lea & Febiger, NY.
Sagarin & balsam M S Cosmetic Science and Technology, Vol 1-3, 2nd ed John Wiley &
Sons, NY.
Salle A J, Fundamental Principles of bacteriology .
Schroff M L, Professional Pharmacy, Five Star Enterprises, Calcutta .
Shotton E and Ridgaway K, Physical Pharmaceutics Oxford University Press, London.
Standury P F & Whitaker A. Principles of Fermentation Technology Pergamon Press,
Oxford.
Stanier R Y, Ingraham, General Microbiology, Wheellis and Painter.
Stoklosa M J, Pharmaceutical Calculation, Lea & Febiger, Philadelphia. Sykes G,
Disinfection and sterilization, IIed.
The Merck Index, Mark & Co., Inc NJ.
The British Pharmaceutical Codex, The Pharmaceutical Press, London. Convention,
Mack Pub Co, Easton. P A.
Thomssen S G, Modem Cosmetics, Universal Publishing Corporation, Bombay.
Turco S and King R E, Sterile Dosage Forms Lea and Febiger, Philadelphia. Wagner J G,
Fundamentals of Clinical Pharmacokinetics, Drug Intelligence Publications, Hamilton.
Wagner J G, Pharmacokinetics for the Pharmaceutical Scientist, Technomic Publishing A
G Basel, Switzerland.
Ward 0 P Fermentation Technology, Principles, Processes & Products· Open University
Press, Milton Keynes, UK.
Winter M E, Basic Clinical Pharmacokinetics, Applied Therapeutics, Ine San fransisco.
Welling Peter G and Tse Francis L S, Pharmacokinetics, Marcel Dekke Inc., NY
Willing S H, IV, Good Manufacturing Practices for Pharmaceuticals Marcel Dekker Inc
NY
Zatz Joel L, Pharmaceutical Calculations, John Wiley & Sons, NY
II. PHARMACOGNOSY
Atal C K and Kapur B M, Cultivation and utilization of Medicinal plants,
RRL,Jammu.
Barz W., Reinhard E and Zenk M H, Plant Tissue Culture and Its
Biotechnological Application, Springer, Berlin.
Brain K R and Turner T D, The Practical Evaluation of Phyto pharmaceuticals,
Wright - Scientechnica, Bristol.
Chadha K L and Gupta R Advances in Horticulture-Vol. II-Medicinal and
Aromatic Plants, Malhotra Publishing House, New Delhi.
Chopra R N, Nayar S L and Chopra, I C, Glossary of Indian Medicinal Plants, C
SIR, New Delhi.
Clarke ECG, Isolation and Identification of Drugs, The Pharmaceutical Press,
London
De Mayo P, The Chemistry of Natural Products, 2-3, Interscience, New York
Export Potential of Selected Medicinal Plants, preparaed by Basic Chemicals,
Pharmaceuticals and Costmetic Export Promotion Council, Bombay, and other
reports.
Fabn A, Plant Anatomy, 3rd Ed., Pergamon Press, Oxford.
Faulkner D J and Fenical W H, Marine Natural Products Chemistry (NATO
Conference Series 4), Plenum Press, New York.
Gamborg 0 L and Wetter L R, Plant Tissue Culture Methods, National Research
Council of Canada, Saskatchewan.
Gibbs R Darneley, Chemotaxonomy of Flowering Plants, 4 Volumes, McGill
University Press.
Guenther, E,'Me Essential Oils - 4 D VanNostrand Co Inc., New York.
Harborne J B, Biochemistry of Phenolic Compounds, Academic Press, New York.
Harborne JB, Phytochemical Methods, Chapman, and Hall, International
Edition, London.
Henry T A, The Plant Alkaloids, McGraw Hill, New York.
Kokate C K, Practical Pharmacognosy, Vallabh Prakashan, Delhi.
Kokate C K, Purohit A P and Gokhale S B, Pharmacognosy (Degree) Nirali
Prakashan, Pune.
Manitto P, The Biosynthensis of Natural Products, Ellis Horwood, Chichester.
Manske R H F, The Alkaloids, Academic Press, New York.
Martindale, The Extra Pharmacopoeia, Pharmaceutical Society of Great Britain,
London.
Medicinal Plants of India, 1. Indian Council of Medical Research, New Delhi.
Miller L P, Phytochemistry, 1-3 VanNostrand Reinhold Co.,
Nadkarni A K, Indian Materia Medical, 1-2, Popular Prakashan Pvt. Ltd.,
Bombay.
Official Methods of Analysis, Association of Official Analytical Chemists
Publications, Washington.
Peach K., and Tracey M V, Modern Methods of Plant Analysis, 1-4, Narosa
publishing house, New Delhi.
Pharmacopoeia of India, 1985, 1996 Govt. of India, Ministry of Health and
Family Welfare.
Pridham J B, and Swain T., Biosynthetic Pathways in Higher Plants, Academic
Press, New York.
Pridham J B., Terpenoids in Plants, Academic Press, New York.
Reinetrt J and Bajaj Y P S, Applied and Fundamental Aspects of Plant Cell,
Tissue and Organ Culture, Berlin.
Robinson, T., The Biochemistry of Alkaloids, Springer-Verlag, New York. Ross
M S E, and Brain K R., An Introduction to Phytopharmacy, Pitman medical,
Kent.
Schellard E J., Practical Plant Chemistry for Pharmacy Students, Pitman Medical,
London.
Scheuer P 1., Marine Natural Products, Academic press, London.
Sinnott E W., Dunn L c., and Dobzhansky T., Principles of Genetics, Tata
Mcgraw Hill Publishing Co., Limited, New Delhi.
Staba E J., Plant Tissue Culture as a Source of Biomedicinals, CRC Press,
Florida.
Stahl E.,Min Layer Chromatography - A Laboratory Handbook, Springer Verlag,
Berlin.
Street H E., Tissue Culture and Plant Science, Academic Press, London. Stumpf,
P K and Conn E E, 7he Biochemistry of Plants: A Comprehensive Treatise, 1-8,
Academic Press.
Swain T, Chemical Plant Taxonomy, Academic Press, London.
Swain T, Comparative Phytochemistry, Academic Press, London.
The Wealth of India, Raw Materials (all volumes) Council of Scientific and
Industrial Research, New Delhi.
Trease G E and Evans W C, Pharinacognosy, Bailliere Tindall, Eastbourne, U K.
Tyler V C., Brady, L R., and Robers J E., Pharmacognosy, Lea and Febiger,
Philadelphia.
Tyler VE Jr and Schwarting AE., Experimental Pharmacognosy, Burgess Pub.
Co, Minneaplis, Minnesota.
United States Pharmacopoeia, United States Pharmacopoeial Convention Inc.,
Rockville Meddisson.
Wallis T E, Analytical Microscopy, J & A Churchill limited, London.
Wallis T E., Text Book of Pharmacognosy , J & A Churchill Limited, London.
Welsch J R, Fundamentals of Plant Genetics and Breeding, Wiley, New Yak.
Whistler R L., Industrial. Gums, Polysaccharides and their Derivatives, Academic
Press, New York.
Williams S., Official Methods of Analysis, Association of Official Analytical
Chemists Inc., Arlington, Virginia, USA.
Zafar R, Medicinal Plants of India, c. B.S. Publisher, New Delhi.
III. PHYSIOLOGY ANATOMY & HEALTH, PHARMACOLOGY AND
CLINICAL PHARMACY
Applied Therapeutics: The Clinical Use of Drugs, Applied Therapeutics, Inc.
Barar F S K., Text Book of Pharmacology, Interprint, new Delhi.
Best and Taylor's Physiological Basis of Medical Practice, Willium & Wilkins,
Baltimore.
Chaurasia B D, Human Anatomy, Regional & Applied. Part I, II & III, CBS
Publishers and Distributors, New Delhi.
Crossland J and Thomson J H., Essentials of Pharmacology, Harper and Row
Publishers NY
Craig C R and Stitzel R R, Modem Pharmacology, Little Brown and Company,
1994.
Davidson's Principles and Pratice of Medicine, ELBS/Churchill Living Stone.
DiFore Lea SHand Febiger, Atlas of Normal Histology, Philadelphia.
Ganong W F, Review of Medical Physiology, Prentice Hall International.
Ghosh M N., Fundamentals of Experimental Pharmacology, Scientific Book
Agency, Calcutta.
Goodman and Gilman's, The Pharmacological basis of Therapeutics; Editors: J G
Hardman, L E Limbird, P B Molinoss, R W Ruddon and A G Gil, Pergamon
Press.".
Guyton A C, Hall JE., Textbook of Medical Physiology,WB Sannders Company.
Herfindal E T and Hirschman J L., Clinical Pharmacy and Therapeutics. Williams
and Wilkins.
Human Physiology, C C Chatterjee, Medical Allied Agency, Calcutta.
Human Physiology, Subhash Shalya, CBS Publishers & Distributors.
Katzung, B G., Basic and Clinical Pharmacology, Prentice Hall, International.
Keele C A, Neil E and Joels N, Samson Wright's Applied Physiology, Oxford
University Press.
Kulkarni S.K., Handbook of Experimentals Pharmacology, Vallabh Prakashan
Delhi.
Laurence, D R and Bennet P. N., Clinical Pharmacology, Churchill Livingstone.
McNaught, A.B. and Callander R, Illustrated Physiology, Churchill Livingstone.
Mycek M J, Gertner S Band Perper M M, Pharmacology Lippincott's Illustrated
Reviews, Lippincott Company, Philadelphia.
Paul L., Principles of Pharmacology, Chapman and Hall.
Parmer N .S, Health Education and Community Pharmacy, CBS Publishers.
Pharmacotherapy: A Pathophysiological Approach, Dipiro, J L Elsevier.
Rang MP Dale MM, Riter lM., Pharmacology, Churchill Livingstone.
Ranade V G, Text Book of Practical Physiology, Pune Vidyarthi Griha Prakashan,
Pune.
Robbins S L and Kumar V, Basic Pathology, W B Saunders Company.
Tortora G J, and Anagnodokos N P, Principles of Anatomy and Physiology
Harper & Row Publishers N. Y.
T'heoharides T C, Pharmacology, Little Brown and Co ..
Vander A J, Shermati J H and Luciano D S Human Physiology, Tata McGraw
Hill Publishing Co., New Delhi.
IV. PHARMACETUICAL ANALYSIS, PHARMACEUTICAL CHEMISTRY,
BIOCHEMISTRY
Acheson R N, An Introduction to the Chemistry of Heterocyclic Compounds,
Interscience Publishers, New York.
Atherden L M, Bentley and Driver's Text book of Pharmaceutical Chemistry,
Oxford University Press, London.
Bassett J, Denny R C, Jeffery G H, Mendham J, Vogel's Textbook of Quantitative
Inorganic Analysis, ELBS/Longman, London.
Beckett A H and Stenlake J B, Practical Pharmaceutical Chemistry Vol. I and II.,
The Athlone Press of the University of London.
Block J H, Roche E, Soine T 0 and Wilson C 0, Inorganic Medicinal and
Pharmaceutical Chemistry, Lea and Febiger, Philadelphia, P A. Brey W S,
Physical Chemistry and its Biological Applications, Academic press.
Chatten L G, A Textbook of Pharmaceutical Chemistry, Vol. I and II, Marcel
Dekker, New York.
Conn E E ad Stumpf P K, Outlines of Biochemistry, John Wiley and Sons, New
York
Connors K A, A Textbook of Pharmaceutical Analysis, Wiley Interscience,' New
York
Delagado J N and Remers WAR, Eds., Wilson and Giswold's Text book of
Organic Medicinal and Phamaceutical Chemistry, J. Lippincott Co., Philadelphia.
Diseher L A, Modem Inorganic Pharmaceutical Chemistry. Eliel E L,
Stereochemistry of Carbon Compounds, McGraw Hill Book Company, Inc., New
York.
Exploring QSAR Vol; I Fundamentals and Applicatoins in Chemistry and
Biology by C Harish and A Leo Vol. II: Hydrophobic, Electronic and
Steric constants by C Harish, A Leo and D Hockman ACS Book Catalog. Finar 1
L" Organic Chemistry, Vol. I., The Fundamentals and Principles,
ELBS/Longman.
Finar I L, Organic Chemistry, Vol. II ELBS/Longman, London. Foye W C,
Principles of Medicinal Chemistry, Lea & Febiger, Philadelphia. Furniss B S,
Hannaford A J, Smith P W G and Tatehell A R, Vogel's Textbook of Practical
Organic Chemistry, The ELBS/Longman, London.
Harish C, Comprehensive Medicinal Chemistry, Vol. N, Quantitative Drug
Design, Pergamon Press, Oxford.
Harrow B and Mazur A, Textbdok of Biochemistry, W B Saunders Co.,
Philadelphia.
Jayaraman J, Laboratory Manual in Biochemistry, Wiley Eastern Limited, New
Delhi.
Jurs P C, Computer Software Application in Chemistry, John Wiley & Sons, New
York.
Kolthoff 1 M and Stenger V A, Volumetric Analysis, Vol. II Titration Methods,
Interscience Publishers, Inc., New York.
Kitckener J A, Findley's physical Chemistry, (Ed.) Green & Co., London.
Knevel A M and Digangi F E, Jenkin's Quantitative Pharmaceutical Chemistry,
McGraw Hill Book Co., New York.
Laidler K J, Physical Chemistry with Biological Applications, Benjman.
Lehninger A L, Biochemistry, Worth Publisher, Inc., Lehninger A L, Principles of
Biochemistry, CBS Publishers and Distributors.
Ladu B N, Mandel H G and way E L., Fundamentals of Drug Metabolism and
Disposition, William andwelkins Co. 428 E, Preston Street. Baltimore.
Mann F C, and Saunders B C, Practical Organic Chemistry, The English
Language Book Society and logman Group limited, London.
Martin Y C, Quantitative Drug Design - A Critical Introduction (Medicinal
Research Monograpah, Vol. 8) Marcel Dekkes, inc. New York.
Wallwork SC, Physical Chemistry for Students of Pharmacy and Biology,
Longman.
Morrison T R and Boyd R N, Organic Chemistry, Prentice Hall of India, Private
limited, New Delhi.
Martin D W, Mays P A and Redwell V M, Harpers Biochemistry, Lange Medical
Publications.
Mussay RK, Granner DK, Mayos PA and Rodwell Harpers
Biochemistry, Prentice-Hall International, Inc.
Nogrady T, Medicinal Chemistry-A Biochemical Approch, Oxford University
Press, New York, Oxford.
Pali S Rand Prabartak S K D E, Practical Physical Chemistry, Haltone Limited.,
Calcutta.
Plumer D T., An Introduction to Practical Biochemistry, Tata McGraw Hill, New
Delhi.
Pops and Perruns, Computer Aided Drug Design, Academic Press, NY Qadry JS
and Qadry S Z., Text book of Inorganic Pharmaceutical and Medicinal Chemistry,
B. S. Shah Prakashan, Ahmedabad.
Roberts J D and Caserio M C, Basic Principles of Organic Chemistry, W A
Benjamin, Inc., New York.
Reynolds J E F, Martindale, The Extra Pharmacopoeia, The Pharmaceutical Press,
London.
Stryer L, Biochemistry, W H Freeman and Company; SanFransisco.
Suchla G., Vogel's Textbook of Micro and Semimicro Qualitative Inorganic
Analysis, Orient Longman, Hyderabad.
Sykes P, A Guidebook to Mechanism in Organic Chemistry, Orient longman,
New Delhi.
Singh Harkishan and Kapoor, V.K., Organic Pharmaceutical Chemistry, Vallabh
Prakashan, Delhi.
Vogel A I, A Text book of practical organic chemistry, The English language
book society and long man group limited, London.
Shoemaker D P, Garland C W, Experiments in Physical Chemistry, McGraw Hill
Book Co., New York.
Wolff M E, Ed. Burger's Medicinal Chemistry, John Wiley & Sons, New York.
Williams V R and Williams H S, Basic Physical Chemistry for the Life Sciences,
W H Freeman.
V. BASIC ELECTRONICS & COMPUTER APPLICATIONS
Grogona P, Programming in Pascal, Adeison Wesley, Reading, M A .. Hunt N
and Shelley J. Computers and Commonsense, Prentice _ Hall of India, New
Delhi.
Jensen K and Wirth N., Pascal User Mannual and Report, Narosa Publishing
House, New Delhi.
Popst and Perrum "Computer Aided Drug Design", Academic Press, New York.
Rajanunan v, Computer Pr08rnmmiug iu Pascal, Prentice- Hall of India, New
Delhi, I983.
Wirth N, Systematic Programming an Introduction, Prentice Hall Englewood
Cliff's New Jersey.
VI. Mathematics
A Textbook of mathematics for XI-XII Students, NCERT Publications, vol. I-IV
Boltons, Pharmaceutical Statistics. Practical and Clinical Applications, MeeceI
Dekker, N Y.
Daniel W W, Biostatistics. A Foundation for Analysis in Health Sciences, John
Wiley, NY.
Grewal B S, Higher Engineering Mathematics, Khanna Publishers, New Delhi.
Gupta S P, Statistical Methods, Sultan Chand & Co., New Delhi.
Schaum, Differential Equations, McGraw- Hill Singapore.