Indian researchers discovered new nano particle drug that delivered via nose | imdip

Most of the time, the route of drug administration is oral or injection. But there are some side effects and that's why the total efficiency of the drug is not used. To decrease these side effects and to increase the efficiency of the drug,

Indian researchers have discovered a new nanotechnology-based drug delivery system that is designed to administer through the nose.

They have found that neuropathic drugs (pain killer for nerve) are more effective when the nanoparticles of the drug are delivered through the nose.

But due to poor permeability of drugs in the nasal membrane was a big problem for the researchers to deliver the drugs through this route of administration.

They didn't give up at that time. They found a solution to this problem.

Indian researchers developed a nanoparticle using Polylactic-co-glycolic acid (PLGA) polymer. To deliver the drug lamotrigine(a commonly used pain killer of the nerve).

The polymer is used to slowly release the nerve painkiller drug in the target area to get long term effect.

To test the efficiency of the formulation, researchers done a comparing test using rats.

They created an aqueous solution of lamotrigine and delivered it through the oral route. They found that most of the gastrointestinal route.

But when the nanoparticle of the drug is delivered through the nose and the more amount of drug is found in the brain.

The high permeability and small size are the reason for the nanoparticle to reach the brain that the aqueous solution of lamotrigine.

According to the report of Indian Science Wire "The promising results of the study done on rats suggest that the drug can be transported to the brain via nasal route. Further pharmacokinetic studies need to be done. Scale up studies to optimize drug loaded on nanoparticles formulations need to be done. Formulating these nanoparticles in the form of nasal creams, gels or aerosols can provide an alternative approach and an outpatient (OPD) option for patients," explained Dr. Shweta Dang, author of the study and Associate Professor at Jaypee Institute of Technology.

The researcher team included Kuldeep Nigam, Atinderpal Kaur, Reema Gabrani and Shweta Dang (Jaypee Institute of Technology); Amit Tyagi (Defence Research and Development Organization); Md Nematullah and Farah Khan (Jamia Hamdard University).